New tirucallane-type triterpenoids from the resin of Boswellia carterii and their NO inhibitory activities  

作　　者：LIU Fang-Shen ZHANG Ting-Ting XU Jun JING Qin-Xue GONG Chi DONG Bang-Jian LI Da-Hong LIU Xiao-Qiu LI Zhan-Lin YUAN Zhong HUA Hui-Ming 

机构地区：[1]Key Laboratory of Structure-Based Drug Design&Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China [2]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China [3]State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,and Tianjin Key Laboratory of Molecular Drug Research,Nankai University,Tianjin 300071,China

出　　处：《Chinese Journal of Natural Medicines》2021年第9期686-692,共7页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81973465);the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX09735005);the Key Laboratory Basic Research Projects of the Department of Education in Liaoning Province,China(No.LZ2014044)。

摘　　要：Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compounds were clarified.The experimental electronic circular dichroism spectra were compared with those calculated,which allowed to assign the absolute configurations.Compounds 5 and 6 possesed a 2,3-seco tirucallane-type triterpenoid skeleton,which were first reported.Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated.Compound 9 showed appreciable inhibitory effect,with an IC_(50)value of 7.58±0.87μmol·L^(-1).

关 键 词：Boswellia carterii Birdw seco-Tirucallane triterpenoids NO inhibition 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]