铁催化合成1,3,5-三芳基-1,5-戊二酮类化合物  

Synthesis of 1,3,5-Triaryl-1,5-pentanediones Catalyzed by Iron

作　　者：刘娥[1] 李立威[1] 姚明 王洪林[1] LIU E;LI Li-wei;YAO Ming;WANG Hong-lin(College of Chemical Engineering and Pharmacy,Jingchu University of Technology,Jingmen 448000,China)

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《化学试剂》2021年第10期1452-1455,共4页Chemical Reagents

基　　金：湖北省教育厅优秀中青年团队项目(T2020023);荆楚理工学院科研项目(ZD201902,ZD202105)。

摘　　要：以苯乙酮和苄醇为原料,碱性条件下以铁催化剂一锅法得到1,3,5-三芳基-1,5-戊二酮,进而对底物进行拓展,得到7种目标化合物,同时对反应条件进行优化。结果表明,叔丁醇钾为碱、二甲苯为溶剂,铁催化剂用量为10 mol%,得到较高产率的目标化合物,结构经^(1)HNMR和^(13)CNMR确证。该方法具有操作简单、反应条件温和、后处理简单、产率较高的特点。Using acetophenone and benzyl alcohol as raw materials,1,3,5-triaryl-1,5-pentanedione was synthesized in one pot with iron catalyst under alkaline conditions.Then,seven 1,3,5-triaryl-1,5-pentanediones were obtained by the substrate scope.Meanwhile,the reaction conditions were optimized.The results showed that 1,3,5-triaryl-1,5-pentanediones were obtained in high yields by using potassium tert butyl alcohol as the base,xylene as the solvent and 10 mol%iron as the catalyst.The structure of the compound was confirmed by ^(1)HNMR and ^(13)CNMR.The method has the advantages of simple operation,mild reaction conditions,the simple work up procedure and high yield.

关 键 词：1 3 5-三芳基-1 5-戊二酮 铁催化剂 一锅法 合成 拓展 

分 类 号：O625.1[理学—有机化学]