微波辐射和物理加热对大麻素酸脱羧反应影响对比分析  

Comparison of the effects on the decarboxylation of cannabinoid acids via microwave radiation and physical heating

作　　者：高宝昌[1] 田媛[1] 石雨[1] 张旭[1] 崔宝玉[1] 孙宇峰[1] GAO Baochang;TIAN Yuan;SHI Yu;ZHANG Xu;CUI Baoyu;SUN Yufeng(Daqing Branch of Heilongjiang Academy of Sciences,Daqing 163316)

机构地区：[1]黑龙江省科学院大庆分院,大庆163316

出　　处：《分析试验室》2021年第9期1049-1052,共4页Chinese Journal of Analysis Laboratory

基　　金：黑龙江省自然科学基金(LH2020B022);黑龙江省科学院科学研究基金(20190401,ZNBZ2019DQ04)资助。

摘　　要：四氢大麻酚和大麻二酚通常以酸性(羧化)形式存在于大麻植物组织中,利用液相色谱方法研究微波辐射和物理加热对大麻素酸的脱羧反应影响,通过测定不同时间下脱羧中性产物含量的方式比较脱羧反应效率。研究表明微波辐射能够选择性作用于大麻素酸分子结构上的羧基官能团,从而导致羧基端发生偶极转向极化和界面极化,在60℃的条件下迅速完成脱羧反应,微波辐射相比于物理加热的脱羧效率显著提高。The cannabinoidsΔ9-THC and CBD are commonly present in Cannabis sativa L.,naturally in their acidic forms.The effect of the decarboxylation of cannabinoid acid by microwave radiation was studied via analyzing the content of the neutral products using liquid chromatography,and the decarboxylation efficiency was compared with that using physical heating decarboxylation method.The mechanism analysis showed that microwave energy can selectively act on the carboxylic functional groups on the molecular structure of cannabinoid acid,resulting in dipole shift polarization and interface polarization of the carboxylic functional groups.The rapid decarboxylation reaction was completed at 60℃.The assay results indicate that microwave radiation has significant improvement in efficiency compared with physical heating decarboxylation method.

关 键 词：大麻素酸 微波辐射 物理加热 对比分析 

分 类 号：O657.72[理学—分析化学]