胃癌前病变不同中医证型患者血清MG7-Ag水平的研究  

Study on serum MG7-Ag level in patients with different TCM syn­drome types of precancerous lesions of gastric cancer

作　　者：于晓雯[1] 付玉 魏凌 瞿旻晔 席彪[1] 陈璇[5] 史亚祥[1] Yu Xiao-wen;Fu Yu;Wei Ling;Qu Min-ye;Xi Biao;Chen Xuan;Shi Ya-xiang(Department of Gastroenterology,Zhenjiang Affiliated Hospital of Nanjing University of traditional Chinese medicine,Zhenjiang 212000,China;Department of encephalopathy,Zhenjiang Affiliated Hospital of Nanjing University of traditional Chinese medicine,Zhenjiang 212000,China;Department of laboratory,Zhenjiang Affiliated Hospital,Nanjing University of traditional Chinese medicine,Zhenjiang 212000,China;Department of traditional Chinese medicine,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China;Department of traditional Chinese medicine,Suzhou science and Technology City Hospital Affiliated to Nanjing Medical University,Suzhou 215000,China)

机构地区：[1]南京中医药大学镇江附属医院脾胃病科,江苏镇江212000 [2]南京中医药大学镇江附属医院脑病科,江苏镇江212000 [3]南京中医药大学镇江附属医院检验科,江苏镇江212000 [4]江苏大学附属医院中医科,江苏镇江212000 [5]南京医科大学附属苏州科技城医院中医科,江苏苏州215000

出　　处：《医学食疗与健康》2021年第18期20-21,25,共3页Medical Diet and Health

基　　金：苏中医科教[2019]8号《第三批江苏省老中医药专家学术经验继承》项目(SYS2019009)。

摘　　要：目的:本研究旨在探讨胃癌前病变(Precancerous lesions of gastric cancer,PLGC)患者血清胃癌单克隆抗体7相关抗原(monoclonal gastric cancer 7 antigen,MG7-Ag)水平与中医证型的关系。方法:对南京中医药大学镇江附属医院收治的PLGC患者进行前瞻性横断面研究。并用ELISA法测定血清MG7-Ag水平。结果:共收治PLGC患者200例,其中男性91例,女性109例。脾胃湿热证、胃阴不足证、肝胃郁热证、肝胃气滞证、脾胃虚弱证及胃络血瘀证患者MG7-Ag水平分别为(3.44±1.82)U/mL、(4.32±1.92)U/mL、(3.81±1.67)U/mL、(3.65±1.70)U/mL、(4.02±2.07)U/mL、(5.60±1.93)U/mL,组间比较差异有统计学意义(P<0.05)。结论:胃阴不足证与胃络瘀血证PLGC患者血清MG7-Ag水平最高,可作为筛选高危人群进行内镜精查的参考,提高早期胃癌的检出率。Objective:The purpose of this study was to explore the relationship between serum monoclonal gastric cancer 7 antigen(MG7-Ag)level and TCM Syndrome Types in patients with Precancerous lesions of gastric cancer(PLGC).Methods:A prospective cross-sectional study was conducted on PLGC patients treated in Zhenjiang Affiliated Hospital of Nanjing University of traditional Chinese medicine.Serum MG7 Ag level was measured by ELISA.Results:A total of 200 patients with PLGC were treated,including 91 males and 109 females.The levels of MG7 Ag were(3.44±1.82)U/mL,(4.32±1.92)U/mL,(3.81±1.67)U/mL,(3.65±1.70)U/mL,(4.02±2.07)U/mL and(5.60±1.93)U/mL in patients with spleen stomach damp heat syndrome,stomach yin deficiency syndrome,liver stomach stagnation syndrome,spleen stomach qi stagnation syndrome and stomach collateral blood stasis syndrome,respectively,The difference was statistically significant(P<0.05).Conclusion:The level of serum MG7 Ag in PLGC patients with gastric Yin deficiency syndrome and gastric collateral blood stasis syndrome is the highest,which can be used as a reference for screening high-risk groups for endoscopic examination and improving the detection rate of early gastric cancer.

关 键 词：癌前病变 胃癌 MG7-AG 危险因素 中医药 癌症危险性 

分 类 号：R753.2[医药卫生—皮肤病学与性病学]