肠道菌群紊乱与女性生殖内分泌疾病相关性研究现状  

Relationship between gut microbiota and female reproductive endocrine diseases

作　　者：张碧云 肖小敏[2] 钟兴明 苗竹林 李蕾蕾 黄丽艳 Zhang Biyun;Xiao Xiaomin;Zhong Xingming;Miao Zhulin;Li Leilei;Huang Liyan(Department of Gynecology,Guangdong Provincial Fertility Hospital,NHC Key Laboratory of Male Reproduction and Genetics,Guangdong Provincial Reproductive Science Institute,Guangzhou 510600,Guangdong Province,China;Department of Obstetrics and Gynecology,First Affiliated Hospital of Jinan University,Guangzhou 510660,Guangdong Province,China;Department of Reproductive Immunology and Endocrinology,Guangdong Provincial Fertility Hospital,Guangzhou 510660,Guangdong Province,China)

机构地区：[1]广东省生殖医院妇科,国家卫生健康委员会男性生殖与遗传重点实验室,广州510600 [2]暨南大学附属第一医院妇产科,广州510660 [3]广东省生殖医院生殖免疫及内分泌科,广州510660

出　　处：《中华妇幼临床医学杂志（电子版）》2021年第4期488-491,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：广东省自然科学基金资助项目(2016A030313760);广州市科技计划项目(201510010253)。

摘　　要：肠道菌群、宿主和环境3者密切关联,构成机体平衡的肠道微生态系统,肠道菌群参与宿主多项生理功能。肠道菌群结构平衡在宿主神经系统、内分泌系统及全身性疾病中扮演着重要角色。在生殖内分泌疾病中,与肠道菌群紊乱的相关性研究尚处于起步阶段。既往研究结果显示,肠道菌群紊乱与阴道内环境变化相关,亦参与多种生殖内分泌疾病,如多囊卵巢综合征(PCOS),子宫内膜异位症等的发生、发展及转归。因此,调节肠道菌群对女性生殖内分泌疾病的治疗有积极意义。笔者拟就肠道菌群紊乱参与生殖内分泌疾病的作用机制的最新研究进展进行阐述。The gut microbiota,host and environment are closely related and constitute a balanced intestinal micro-ecosystem,and gut microbiota is involved in several of physiological functions of the host.The structural balance of gut microbiota plays an important role in nervous system,neuroendocrine and other systemic diseases of the host.However,in the field of reproductive endocrinology,studies on gut microbiota are still in the preliminary stage.Previous findings have shown that gut microbiota disorder is involved in the onset,development and regression of several reproductive endocrine system-related diseases.Gut microbiota disorder is associated with polycystic ovary syndrome(PCOS),endometriosis,and vaginal endoenvironment.Therefore,the regulation of gut microbiota has positive implications for the treatment of diseases related to the female reproductive endocrine system.The author intends to explore the relationship and the mechanism between gut microbiota and common reproductive endocrine diseases.

关 键 词：细菌结构 女(雌)性泌尿生殖系统疾病 多囊卵巢综合征 早发性卵巢功能不全 青春期 早熟 肠道菌群紊乱 肠道微生态系统 女(雌)性 

分 类 号：R71[医药卫生—妇产科学]