血清BNP、CRP预测急性ST段抬高型心肌梗死患者PCI后不良心血管事件的价值研究  

The value of serum BNP and CRP levels in predicting the incidence of short-term adverse cardiovascular events in patients with acute ST elevated myocardial infarction after PCI

作　　者：杨启才[1] 姜荣泸[1] 任凌[1] YANG Qicai;JIANG Ronglu;REN Ling(Department of Cardiology,Yibin First People’s Hospital,Sichuan,Yibin 644000,China)

机构地区：[1]四川省宜宾市第一人民医院心血管内科,644000

出　　处：《河北医药》2021年第19期2951-2954,共4页Hebei Medical Journal

摘　　要：目的分析血清脑钠肽(BNP)、C-反应蛋白(CRP)水平在急性ST段抬高型心肌梗死(STEMI)患者PCI后短期内不良心血管事件(MACE)发生的预测价值。方法回顾性分析2018年1月至2019年12月宜宾市第一人民医院心血管内科接受PCI治疗后随访1个月内发生MACE的41例急性STEMI患者资料为发生MACE组,收集医院同期接受PCI治疗后随访1个月内未发生MACE的41例急性STEMI患者资料为未发生MACE组。全部患者入院当天均接受实验室相关指标检测,且检测结果资料完整。重点统计并比较2组入院当天血清BNP、CRP检测结果数据及主要基线资料,观察BNP、CRP水平对急性STEMI患者PCI后短期内MACE发生预测价值。结果发生MACE组血清BNP、CRP水平均高于未发生MACE组,差异有统计学意义(P<0.05);回归分析结果显示,血清BNP、CRP异常表达与急性STEMI患者PCI后短期内发生MACE有关,二者过表达可能是急性STEMI患者PCI后短期内发生MACE的风险因子(OR>1,P<0.05);绘制ROC曲线,结果显示,血清BNP、CRP预测急性STEMI患者PCI后短期内发生MACE风险的AUC均>0.80,预测价值较为理想。结论急性STEMI患者入院时血清BNP、CRP水平与PCI后短期内MACE发生有关,二者过表达可能提示MACE高风险,用于预测MACE风险有一定价值。Objective To investigate the value of serum brain natriuretic peptide(BNP)and C-reactive protein(CRP)levels in predicting the incidence of short-term adverse cardiovascular events(MACE)in patients with acute ST elevated myocardial infarction(STEMI)after PCI.Methods A total of 41 patients with acute STEMI who were treated by PCI in our hospital from January 2018 to December 2019 who had MACE within 1-month follow-up were enrolled as MACE group,at the sanmme time,the other 41 patients who did not occur MACE were enrolled as non MACE group.The results of serum BNP and CRP and the main baseline data were observed and compared between the two groups to analyze the predictive value of BNP and CRP levels for the incidence of short-term MACE.Results The serum levels of BNP and CRP in MACE group were significantly higher than those in non MACE group(P<0.05).The Logistic regression analysis showed that the abnormal expression of serum BNP and CRP was associated with the incidence of short-term MACE in patients with acute STEMI after PCI,and the overexpression of two indexes might be the risk factors of short-term MACE(P<0.05).The ROC curve was drawn,and the results showed that the AUC of serum BNP and CRP in predicting the risk of short-term MACE was over 0.80,and the predictive value was ideal.Conclusion The serum BNP and CRP levels in patients with acute STEMI on admission are associated with the incidence of short-term MACE after PCI,and the overexpression of the two indexes may indicate high risk of MACE,which has certain value in predicting the risk of MACE.

关 键 词：急性ST段抬高型心肌梗死 脑钠肽 C-反应蛋白 不良心血管事件 预测 

分 类 号：R542.22[医药卫生—心血管疾病]