乙醛脱氢酶2基因多态性与心血管疾病的研究进展  

Research progress of the correlation between ALDH2 gene polymorphism and cardiovascular diseases

作　　者：林加龙 徐伍 李运明 张信琴 徐瑞 李秀川 汪雄王永华 李公任 裴海峰 LIN Jialong;XU Wu;LI Yunming(Nursing College,Chengdu Medical College,Sichuan,Chengdu 610500,China;不详)

机构地区：[1]成都医学院护理学院护理学,成都市610500 [2]成都中医药大学医学与生命科学学院 [3]中国人民解放军西部战区总医院信息科 [4]中国人民解放军西部战区总医院心内科 [5]中国人民解放军西部战区总医院护理部 [6]西南交通大学医学院

出　　处：《河北医药》2021年第19期3000-3005,共6页Hebei Medical Journal

摘　　要：心血管疾病作为一类高发疾病,正以其高致死率和严重并发症威胁着人类生命和生活质量,因此对心血管疾病的防治工作显得尤为重要。乙醛脱氢酶2(aldehyde dehydrogenase 2,ALDH2)作为在人体内广泛分布的线粒体蛋白,其活性取决于编码基因的多态性。多项研究已经证实ALDH2在多种心血管疾病中发挥着重要的保护作用,但其作用机制尚存争议。故本文主要针对ALDH2基因多态性与心血管疾病间的研究进展作一综述,以期为心血管疾病的预防和治疗提供新的思路和方向。As a kind of high incidence diseases,cardiovascular diseases are threatening human’s lives and quality of life due to their high mortality and serious complications.Therefore,the prevention and treatment of cardiovascular diseases are particularly important.Aldehyde dehydrogenase 2(ALDH2),as a mitochondria protein widely distributed in human bodies,its activity depends on the polymorphism of coding gene.Many studies have confirmed that ALDH2 plays an important protective role in many cardiovascular diseases,but its mechanism is still controversial.Therefore,this article mainly reviews the research progress of the correlation between ALDH2 gene polymorphism and cardiovascular diseases,so as to provide new ideas and directions for the prevention and treatment of cardiovascular diseases.

关 键 词：乙醛脱氢酶2 基因多态性 心血管疾病 研究进展 

分 类 号：R543[医药卫生—心血管疾病]