激素避孕药具的非避孕用途及安全性研究进展  

Progress in non-contraceptive effects and safety of hormonal contraceptives

作　　者：朱焰 王健 Zhu Yan;Wang Jian(NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies),Fudan University,Shanghai 200032,China)

机构地区：[1]上海市生物医药技术研究院,国家卫生健康委员会计划生育药具重点实验室,200032

出　　处：《中华生殖与避孕杂志》2021年第8期723-730,共8页Chinese Journal of Reproduction and Contraception

基　　金：上海市自然科学基金(20ZR1448200);国家重点研发项目(2016YFC1000904)。

摘　　要：我国目前同时面临着人工流产率不断攀升、辅助生育市场蓬勃发展的奇特现象,表明育龄人群的生育力受到损伤。避孕药具是防止非意愿妊娠、减少人工流产唯一有效的方法,其带来的获益远远大于人工流产带来的风险。一些避孕药还具有非避孕益处以及额外的治疗价值,但同时也伴随着一定的不良反应。深入了解激素类避孕药的药理特性和安全性,为不同年龄和不同需求的人群提供适宜的避孕药具有助于促进避孕药具正确、合理地应用,使之成为保护育龄人群生育功能的重要措施。本文将追踪和介绍近十年来国外新型激素避孕药具产品、非避孕用途和安全性研究进展,为国内避孕药具的研发和应用提供参考。China is currently facing an abnormal phenomenon in which both artificial abortion rate and assisted reproductive market are rising,suggesting that the fertility of women has been injured.Contraceptives are the only effective way to reduce the artificial abortion from unintended pregnancy,and the benefits they bring far surpass the risks of abortion,and some of contraceptives have extra therapeutic value.However,the efficacy of hormonal contraceptives is also accompanied by unwanted adverse effects as well.Understanding the pharmacological properties and the adverse effects of the contraceptives will conduce to use them properly according to the requirements of all ages,making the contraceptives an important measure to protect the fertility of women.This article will summarize the progress in research and development,non-contraceptive uses and the safety of the contraceptives in the past 10 years,providing new information for the readers.

关 键 词：激素避孕药 非避孕用途 药理特性 不良反应 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]