探讨新生儿肺炎治疗中运用多巴酚丁胺联合盐酸氨溴索雾化吸入的临床效果及对血清炎性因子的影响  

The Clinical Effect of Dobutamine Combined with Ambroxol Hydrochloride Inhalation in the Treatment of Neonatal Pneumonia and Its Influence on Serum Inflammatory Factors

作　　者：朱莉莉 周俊霞 张利敏[1] 赵晓卫[1] 王庆敏 王东英 Zhu Lili;Zhou Junxia;Zhang Limin;Zhao Xiaowei;Wang Qingmin;Wang Dongying(Department of Neonatology,Zhengzhou No.7 People's Hospital,Zhengzhou 450004)

机构地区：[1]郑州市第七人民医院新生儿科,郑州450004

出　　处：《数理医药学杂志》2021年第10期1484-1487,共4页Journal of Mathematical Medicine

摘　　要：目的:探究新生儿肺炎治疗中运用多巴酚丁胺联合盐酸氨溴索雾化吸入的临床效果及对血清炎性因子的实际影响。方法:选取2018年2月~2020年2月间某院儿科接诊的110例新生儿肺炎患者,按双盲法分为对照组和观察组各55例,对照组予以常规治疗联合盐酸氨溴索治疗,观察组在以上基础增加多巴酚丁胺治疗,观察对比两组患儿的临床疗效。结果:经治疗后,观察组患儿的临床总有效率(94.55%)明显高于对照组(76.36%)(P<0.05);观察组患儿的PaCO 2指标水平明显低于对照组患儿,PaO 2指标水平明显高于对照组患儿(P<0.05);观察组患儿的CRP、IL-6、IL-10指标水平明显低于对照组患儿,IL-2指标水平明显高于对照组患儿(P<0.05);观察组患儿的不良反应总发生率(3.64%)明显低于对照组患儿(16.36%)(P<0.05)。结论:在新生儿肺炎治疗中运用多巴酚丁胺与盐酸氨溴索联合治疗,既可提高临床总疗效,又可显著改善患儿的血气指标与血清炎性指标,安全性更高,值得临床推荐。Objective:To explore the clinical effect of dobutamine combined with ambroxol hydrochloride nebulized inhalation in the treatment of neonatal pneumonia and its actual effect on serum inflammatory factors.Methods:A total of 110 neonatal pneumonia patients admitted to a hospital from February 2018 to February 2020 were selected and divided into two groups according to the double-blind method for study.The 55 children in the control group were treated with conventional treatment combined with ambroxol hydrochloride,and the 55 children in the observation group were treated with dobutamine on the above basis.The clinical efficacy of the two groups of children was observed and compared.Results:After treatment,the total clinical effective rate of children in the observation group(94.55%)was significantly higher than that of the control group(76.36%)(P<0.05).The PaCO 2 index level of children in the observation group was significantly lower than that of the control group,and the PaO 2 index level was significantly higher than that of the control group(P<0.05).The CRP,IL-6,and IL-10 index levels of the observation group were significantly lower than those of the control group,and the IL-2 index level was significantly higher than that of the control group(P<0.05).The total incidence of adverse reactions in the observation group(3.64%)was significantly lower than that in the control group(16.36%)(P<0.05).Conclusion:The combined treatment of dobutamine and ambroxol hydrochloride in the treatment of neonatal pneumonia can not only improve the overall clinical efficacy,but also significantly improve the blood gas and serum inflammatory indexes of the child,with higher safety,which is worthy of clinical recommendation.

关 键 词：新生儿肺炎 多巴酚丁胺 盐酸氨溴索 雾化吸入 血清炎性因子 

分 类 号：R722.19[医药卫生—儿科]