色氨酸代谢与肾脏疾病互作研究进展  

Crosstalk between tryptophan metabolism and kidney disease,mechanisms and therapeutic implications

作　　者：谭蓓 张尊建[1] 许风国[1] 张培[1] TAN Bei;ZHANG Zunjian;XU Fengguo;ZHANG Pei(Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009

出　　处：《药学研究》2021年第9期598-604,共7页Journal of Pharmaceutical Research

基　　金：国家自然科学基金项目(No.82073812、81773861、81773682);江苏省杰出青年科学基金(No.BK20180027);中央高校基本科研业务费专项资金(No.2632021PY03)。

摘　　要：急性肾损伤(AKI)、慢性肾病(CKD)与肾癌(RCC)是临床上典型的肾脏疾病,其发病机制复杂且易诱发多种并发症而造成全身性损伤。近年来的研究揭示,色氨酸代谢与抑郁症、自身免疫性疾病、神经退行性疾病与癌症等疾病的发生发展密切相关,其在肾脏疾病的发生发展过程中亦发挥着重要作用。本文综述了色氨酸代谢与急性肾损伤、慢性肾病及肾癌等肾脏疾病的互作研究进展,总结分析了靶向色氨酸代谢的肾脏疾病干预策略,以期为肾脏疾病诊断和防治提供借鉴。Acute kidney injury(AKI),chronic kidney disease(CKD)and renal cell carcinoma(RCC)are typical kidney diseases in clinic that have complex pathogenesis and can induce multiple complications and systemic damage.Tryptophan metabolism has been reported to participate in the occurrence and development of various diseases including depression,autoimmunity,neurodegeneration and cancer.Particularly,it is heavily involved in the pathogenesis of kidney disease.This paper reviewed crosstalk between tryptophan metabolism and kidney disease(i.e.,AKI,CKD and RCC)and summarizes potential therapeutic remedies by intervening tryptophan metabolism,aiming to provide ideas for kidney disease therapies targeting small molecule metabolism.

关 键 词：色氨酸代谢 急性肾损伤 慢性肾病 肾癌 

分 类 号：R692[医药卫生—泌尿科学]