军团菌耐药现状及耐药机制研究进展  

Current status and mechanism of drug resistance of Legionella

作　　者：赵子睿 张怡 李萍[1] 陈愉[1] Zhao Zirui;Zhang Yi;Li Ping;Chen Yu(Department of Respiratory and Critical Care Medicine,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院呼吸与危重症医学科,沈阳110004

出　　处：《国际呼吸杂志》2021年第17期1286-1290,共5页International Journal of Respiration

基　　金：科技部重点研发计划资助项目(2017YFC1309702);国家自然科学基金(81170009)。

摘　　要：军团菌广泛存在于自然界及人工水系,可引起重症肺炎,病死率高。大环内酯和氟喹诺酮类药物是其主要治疗药物,目前已发现其耐药的发生,临床上一旦发生耐药,将影响预后。本文对环境及临床军团菌菌株的耐药现状及可能的耐药机制进行介绍,为临床医生对军团菌肺炎患者治疗决策的制定和调整提供参考。Legionella widely exists in nature and artificial water system,which can cause severe pneumonia with high mortality.Macrolides and fluoroquinolones are the main therapeutic drugs.At present,the occurrence of drug resistance has been found.Once drug resistance occurs in clinic,it will affect the prognosis.In this paper,the current status of drug resistance of environmental and clinical Legionella strains and the possible mechanism of drug resistance were introduced,so as to provide reference for clinicians to make and adjust the treatment decision of Legionella pneumonia patients.

关 键 词：肺炎 细菌性 长滩军团菌 抗药性 细菌 药物疗法 

分 类 号：R446.5[医药卫生—诊断学]