泌尿系统感染合并血流感染高危因素探讨  

Investigation of the high risk factors of urinary tract infection combined with bloodstream infection

作　　者：王学满 陈中举 田磊 闫少珍 汪玥 朱旭慧 李丽[1] WANG Xue-man;CHEN Zhong-ju;TIAN Lei(Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院检验科,湖北武汉430030

出　　处：《中国实验诊断学》2021年第9期1285-1287,共3页Chinese Journal of Laboratory Diagnosis

基　　金：湖北省自然科学基金一般面上项目(2019CFB666)。

摘　　要：目的分析引发泌尿系统感染合并血流感染的高危因素。方法选取147例泌尿系统感染患者为研究对象,以是否合并血流感染为条件分为合并血流感染组(66例)与非合并血流感染组(81例),回顾性分析并比较各组同时期尿白细胞含量、血小板浓度(PLT)、C反应蛋白(CRP)水平、空腹血糖水平、白蛋白(ALB)水平、D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)及抗凝血酶Ⅲ(ATⅢ)水平。结果合并血流感染组CRP水平、空腹血糖水平、D-D、PT、APTT和FIB明显高于非合并血流感染组,差异具有统计学意义(P<0.05),合并血流感染组PLT、ALB水平及ATⅢ明显低于非合并感染组,差异具有统计学意义(P<0.05),两组之间年龄、性别分布、TT及尿白细胞含量无明显统计学意义的差别(P>0.05)。Spearson相关分析显示泌尿系统感染合并血流感染与CRP、空腹血糖水平、D-D、PT、APTT和FIB呈正相关性(P<0.05),与PLT、ALB及ATⅢ呈负相关性(P<0.05)。结论PLT、CRP水平、空腹血糖水平、ALB水平、D-D、PT、APTT、FIB及ATⅢ水平为泌尿系统感染合并血流感染的高危因素。Objective To analyze and discuss the high risk factors of urinary tract infection combined with blood-stream infection.Methods One hundred and forty-seven patients with urinary tract infection were selected as research objects.They were divided into group of 66 cases with combined bloodstream infection and group of 81 cases without combined bloodstream infection.Compare and analysis the levels of urinary leukocyte,platelet concentration(PLT),Creactive protein(CRP),fasting blood glucose,albumin(ALB),D-D,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)and antithrombin Ⅲ(ATⅢ)in each group retrospectively.Results The levels of CRP,fasting blood glucose,D-D,PT,APTT and FIB in the combined bloodstream infection group were significantly higher than those in the non-combined bloodstream infection group,and the difference was statistically significant(P<0.05).The levels of PLT,ALB and ATⅢ in the combined bloodstream infection group were significantly lower than those in the non-combined infection group,and the difference was statistically significant(P<0.05).There were no significant differences in age,gender distribution,TT and urinary leukocyte content between the two groups(P>0.05).Spearson correlation analysis showed that urinary tract infection combined with bloodstream infection was positively correlated with CRP,fasting blood glucose level,D-D,PT,APTT and FIB(P<0.05),and negatively correlated with PLT,ALB and ATⅢ(P<0.05).Conclusion PLT,CRP,fasting blood glucose,ALB,D-D,PT,APTT,FIB and ATⅢ levels are high risk factors for urinary tract infection complicated with bloodstream infection.

关 键 词：泌尿系统感染 血流感染 C反应蛋白 空腹血糖 血小板浓度 D-D PT APTT TT FIB ATⅢ 

分 类 号：R446.1[医药卫生—诊断学] R446.5[医药卫生—临床医学]