腹腔镜胃肠穿孔修补术后应用生长抑素对改善患者预后的效果分析  

Analysis of the effect of Somatostatin on improving the prognosis of patients after laparoscopic gastrointestinal perforation repair

作　　者：游波[1] 吴长华[1] 邹国桥 余健 江小雪 YOU Bo;WU Chang-hua;ZOU Guo-qiao;YU Jian;JIANG Xiao-xue(Department of Emergency Surgery,Fuzhou First People′s Hospital,Jiangxi Province,Fuzhou 344000,China)

机构地区：[1]江西省抚州市第一人民医院急诊外科,江西抚州344000

出　　处：《中国当代医药》2021年第27期90-93,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划(202141012)。

摘　　要：目的研究腹腔镜胃肠穿孔修补术后应用生长抑素对改善患者预后的效果。方法选取2019年11月至2021年1月于抚州市第一人民医院急诊收治的需进行腹腔镜胃肠穿孔修补术的患者77例,按照随机数字表法分为对照组(39例)和治疗组(38例)。两组患者均进行腹腔镜胃肠穿孔修补术,术后,对照组患者给予补液、抗炎等常规术后治疗,治疗组在术后给予生长抑素。比较两组患者术后恢复情况、住院时间、住院费用、术后炎症因子水平及并发症发生情况。结果治疗组术后肠道功能恢复时间、首次正常进食时间、胃肠减压引流时间、首次排便时间、首次下床时间、引流管留置时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗组住院费用低于对照组,差异有统计学意义(P<0.05)。术后3 d,治疗组血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)水平均低于对照组,差异有统计学意义(P<0.05)。治疗组术后并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论腹腔镜胃肠穿孔修补术后应用生长抑素能有效改善术后恢复情况,降低机体炎症因子水平,缩短住院时间,减少住院费用,且术后并发症总发生率明显降低,较常规术后抗炎治疗预后更佳。Objective To study the effect of Somatostatin on improving the prognosis of patients after laparoscopic gastrointestinal perforation repair.Methods A total of 77 cases of patients undergoing laparoscopic gastrointestinal perforation repair were selected from the Department of Emergency Surgery,Fuzhou First People′s Hospital from November 2019 to January 2021,according to random number table method to divide into control group(39 cases)and treatment group(38 cases).Both groups of patients underwent laparoscopic gastrointestinal perforation repair.Postoperative,patients in the control group were given routine postoperative treatment such as fluid rehydration and anti-inflammatory,the treatment group was given Somatostatin.The postoperative recovery,hospital stay,hospital costs and postoperative inflammatory cytokine levels and the incidence of complications were compared between the two groups.Results Postoperative bowel function recovery time,first normal eating time,gastrointestinal decompression and drainage time,first bowel movement time,first time out of bed,the drainage tube indwelling time and hospital stay in treatment group were shorter than those in the control group,the differences were statistically significant(P<0.05).Hospitalization expenses in the treatment group was lower than that in the control group,the difference was statistically significant(P<0.05).Three days after operation,the serum tumor necrosis factor(TNF)-α,interleukin(IL)-6,and high-sensitivity C-reactive protein(hs-CRP)levels of the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the treatment group is lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Application of somatostatin after laparoscopic repair of gastrointestinal perforation can effectively improve postoperative recovery,reduce the level of inflammatory factors in the body,shorten hospital stay,reduce ho

关 键 词：腹腔镜胃肠穿孔修补术 生长抑素 肿瘤坏死因子 白细胞介素 超敏C反应蛋白 预后 

分 类 号：R614[医药卫生—麻醉学]