斑蝥酸钠维生素B6联合腹腔镜完整肠系膜切除术治疗结肠癌临床研究  

Clinical Study of Sodium Cantharidate Vitamin B6 Combined with Laparoscopic Complete Mesentery Resection in the Treatment of Patients with Colon Cancer

作　　者：李嫦娥 崔庆丰 LI Chang'e;CUI Qingfeng(Qinhuangdao Military Hospital,Qinhuangdao,Hebei,China 066600;The Affiliated Hospital of Hebei University of Technology,Handan,Hebei,China 056002)

机构地区：[1]河北省秦皇岛市军工医院,河北秦皇岛066600 [2]河北工程大学附属医院,河北邯郸056002

出　　处：《中国药业》2021年第19期102-104,共3页China Pharmaceuticals

基　　金：河北省医学科学研究课题[20200583]。

摘　　要：目的探讨斑蝥酸钠维生素B6联合腹腔镜完整肠系膜切除术治疗结肠癌的疗效,以及对患者T淋巴细胞亚群阳性率的影响。方法选取河北省秦皇岛市军工医院2017年4月至2019年4月收治的结肠癌患者130例,按随机数字表法分为手术组和联合组,各65例。手术组患者予腹腔镜完整肠系膜切除术治疗,联合组患者在手术组基础上加用斑蝥酸钠维生素B6治疗,疗程2周,均随访1年。结果联合组的总有效率为95.38%,显著高于手术组的80.00%(P<0.05)。治疗2周后,两组患者白细胞介素6(IL-6)、高速泳动族蛋白B1(HMGB1)、单核细胞趋化因子蛋白1(MCP-1)水平均显著下降,且联合组显著低于手术组(P<0.05)。治疗2周后,两组患者的T淋巴细胞亚群CD3+和CD4+阳性率均显著上升,且联合组显著高于手术组(P<0.05);两组患者的CD8+阳性率均显著下降,且联合组显著低于手术组(P<0.05)。联合组患者随访1年的生存率为98.46%,显著高于手术组的84.62%(P<0.05)。两组不良反应发生率均为3.08%。结论斑蝥酸钠维生素B6联合腹腔镜完整肠系膜切除术治疗结肠癌效果显著,可改善患者的血清炎性因子水平和T淋巴细胞亚群阳性率,延长生存期,且安全性较高。Objective To investigate the efficacy of sodium cantharidate vitamin B6 combined with laparoscopic complete mesentery resection in the treatment of patients with colon cancer and its effect on the positive rates of T lymphocyte subsets.Methods A total of 130 patients with colon cancer admitted to the Qinhuangdao Military Hospital from April 2017 to April 2019 were selected and divided into the operation group and the combined group according to the random number table method,65 cases in each group.The patients in the operation group were treated with laparoscopic complete mesentery resection,on this basis,the patients in the combined group were treated with sodium cantharidate vitamin B6.Both groups were treated for two weeks and followed up for one year.Results The total effective rate of the combined group was 95.38%,which was significantly higher than 80.00%of the operation group(P<0.05).After two weeks of treatment,the levels of interleukin-6(IL-6),high mobility group protein B1(HMGB1)and monocyte chemokine protein 1(MCP-1)in the two groups were significantly lower than those before treatment,and those in the combined group were significantly lower than those in the operation group(P<0.05).After two weeks of treatment,the positive rates of T lymphocyte subsets CD3+and CD4+in the two groups were significantly higher than those before treatment,and those in the combined group were significantly higher than those in the operation group(P<0.05),while the positive rate of CD8+in the two groups was significantly lower than that before treatment,and that in the combined group was significantly lower than that in the operation group(P<0.05).The 1-year survival rate in the combined group was 98.46%,which was significantly higher than 84.62%in the operation group(P<0.05).The incidence of adverse reactions in the two groups was 3.08%(P>0.05).Conclusion Sodium cantharidate vitamin B6 combined with laparoscopic complete mesentery resection is effective and safe in the treatment of patients with colon cancer,which can sign

关 键 词：斑蝥酸钠维生素B6 腹腔镜完整肠系膜切除术 结肠癌 T淋巴细胞亚群 炎性因子 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]