L-半胱氨酸电化学传感器的研究与应用  

Recent advances in developing electrochemical sensors for L-cysteine

作　　者：刘陈 张慢乐 于鑫垚 彭与煜 肖忠良 于冬宏 曹忠[1] Liu Chen;Zhang Man-le;Yu Xin-yao;Peng Yu-yu;Xiao Zhong-liang;Yu Dong-hong;Cao Zhong(Collaborative Innovation Center of Micro/nano Bio-sensing and Food Safety Inspection,Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation,School of Chemistry and Biological Engineering,Changsha University of Science and Technology,Changsha 410114,China;Chongqing Academy of Metrology and Quality Inspection,Chongqing 401123,China;Department of Chemistry and Bioscience,Aalborg University,DK-9220 Aalborg,Denmark)

机构地区：[1]长沙理工大学化学与生物工程学院,电力与交通材料保护湖南省重点实验室,微纳生物传感与食品安全检测协同创新中心,湖南长沙410114 [2]重庆市计量质量检测研究院,重庆401123 [3]奥尔堡大学化学与生物科学系,奥尔堡DK-9220,丹麦

出　　处：《化学传感器》2019年第3期22-31,共10页Chemical Sensors

基　　金：国家自然科学基金(31527803,21545010);湖南省自然科学基金(2020JJ40559)资助。

摘　　要：L-半胱氨酸(L-Cys)是一种重要的含硫氨基酸,其在生物体新陈代谢、生长发育、信号转导、生物防御和衰老中都起着重要作用,且它的浓度异常与相关疾病都息息相关。因此,开发一种具有高效率、高灵敏性和高选择性的快速方法用于痕量水平L-Cys的检测在临床医学和生命科学领域尤为重要。这篇文章介绍了近年来L-Cys的电化学分析方法,重点介绍了电化学传感界面的构建以及不同电化学检测方法的性能比较。L-Cysteine(L-Cys)is one of the most important naturally occurred sulfur-containing amino acids that plays an important role in metabolism,growth,signal transduction,biophylaxis and aging for organisms.And the unsatisfied L-Cys content could induce relevant diseases.Thus,it is highly critical to develop high efficiency sensing methods for the detection of L-Cys at trace levels with high sensitivity and selectivity in clinical medicine and life science fields.This brief review summarized electrochemical methods for detection of L-Cys in recent years,with key focus on the construction of electrochemical sensing interface and the compared performance among different electrochemical detection methods.

关 键 词：L-半胱氨酸 电化学分析 传感器 纳米材料 综述 

分 类 号：O657.1[理学—分析化学] R313[理学—化学]