过敏性紫癜患儿血清IL-4 IL-10 IL-13水平变化及意义  

作　　者：谢晓蕾[1] 沈巍 吴原[1] 黄美玲 钟华杰[1] 

机构地区：[1]浙江省湖州市中心医院(湖州师范学院附属中心医院),313000

出　　处：《浙江临床医学》2021年第9期1309-1311,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科研面上项目(2018KY784)。

摘　　要：目的观察过敏性紫癜(HSP)患儿急性期白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-13(1L-13)的水平变化,并探讨其临床意义。方法选取2018年1月至2019年1月急性期HSP悲儿58例,根据病情特点分为单纯型(皮肤型)及非单纯型(关节型、腹型、肾型)。其中单纯型予复方甘草酸苷片口服治疗(复方甘草酸苷组),非单纯型予波尼松片口服治疗(泼尼松组),两组患者均予氣雷他定糖浆抗过敏,复方芦丁片改善血管通透性,治疗时间均为2周,分別对两组患者治疗前后病情严重程度评分,采用酶联免疫吸附法(ELISA)检测所有患儿治疗前后血清IL-4、IL-10、IL-13水平变化。另选择同时间段本院体检健康儿童60例为对照组。结果波尼松组患儿治疗前血清L-4、IL-10、IL-13水平均高于健康对照组及复方甘草酸将组(P<0.05)。波尼松组患儿治疗后,血清IL-4、IL-10、IL-13水平下降(P<0.05)。复方甘草酸苷组患儿治疗后,血清IL-4、IL-10水平下降(P<0.05)。复方甘草酸苷组治疗前病情严重程度评分低于泼尼松组(P<0.05),两组患者治疗后病情严重程度评分均下降(P<0.05)。复方甘草酸苷组总有效率77.6%,波尼松组总有效率85.7%。结论HSP患儿急性期存在免疫功能紊乱,血清细胞因子IL-4、IL-10、IL-13水平与HSP密切相关,检测相关指标水平并及早采取措施,对HSP的诊治具有重要临床意义。复方甘草酸苷、泼尼松均可有效降低血清细胞因子水平,改善病情严重程度。Objective To observe the levels of interleukin-4(IL-4),interleukin-10(IL-10)and interleukin-13(IL-13)in children with Henoch-Schonlein purpura(HSP)at acute stage,and to explore its clinical significance.Methods From January 2018 to January 2019,58 children with acute allergic purpura in Huzhou central hospital were selected.According to the characteristics of the disease,they were divided into simple type(skin type)and non-simple type(joint type,abdominal type and kidney type).The simple type was given oral treatment of compound glycyrrhizin tablets(hereinafter referred to as compound glycyrrhizin group)and the non-simple type was given oral treatment of prednisone tablets(hereinafter referred to as prednisone group)The treatment time was 2 weeks.The severity of the two groups were scored before and after treatment,and the levels of serum IL-4,IL-10 and IL-13 were detected by enzyme-linked immunosorbent assay(ELISA).60 healthy children in our hospital during the same period were selected as the control group.Results(1)The levek of serum IL-4,IL-10 and IL-13 in prednisone group before treatment were significantly higher than those in healthy control group and compound glycyrrhizin group(P<0.05).(2)After treatment,the levels of serum IL-4,IL-10 and IL-13 in prednisone group decreased(P<0.05).(3)After treatment,the levels of serum IL-4 and IL-10 in compound glycyrrhizin group decreased(P<0.05).(4)The disease severity score of Compound Glycyrrhizin group was lower than that of prednisone group before treatment(P<0.05),and the disease severity score ofboth groups decreased after treatment(P<0.05).(5)The total efiective rate of Compound Glycyrrhizin group was 77.6%,and that of prednisone group was 85.7%.Conclusion(1)There is immune disorder in children with Henoch-Schonlein purpura in acute stage.The levels of serum cytokines IL-4,IL-10 and IL-13 are closely related to HSP.It is of great clinical significance to detect the levels of relevant indicators and take measures as soon as possible for the diagnosis and treatme

关 键 词：过敏性紫癜 白细胞介素-4 白细胞介素-10 白细胞介素-13儿童 

分 类 号：R28[医药卫生—中药学]