加味青娥丸联合温针灸治疗肾虚血瘀型绝经后骨量减少的临床观察  

Clinical Observation of Modified Qing’e Pills Combined with Moxibustion with Warming Needle for Treatment of Postmenopausal Bone Loss of Kidney Deficiency and Blood Stasis Syndrome Type

作　　者：方正中[1,2] 孙奎 宋阳春[1,2] 周章武[3] FANG Zheng-Zhong;SUN Kui;SONG Yang-Chun;ZHOU Zhang-Wu(The Second Hospital Affiliated to Anhui University of Traditional Chinese Medicine,Hefei 230061 Anhui,China;Dept.of Orthopedics,Anhui Provincial Acupuncture Hospital,Hefei 230061 Anhui,China;The First Hospital Affiliated to Anhui University of Traditional Chinese Medicine,Hefei 230031 Anhui,China)

机构地区：[1]安徽中医药大学附属第二医院,安徽合肥230061 [2]安徽省针灸医院骨二科,安徽合肥230061 [3]安徽中医药大学附属第一医院,安徽合肥230031

出　　处：《广州中医药大学学报》2021年第9期1873-1879,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：安徽省科技厅重点研究与开发计划项目(编号:1704f0804034)。

摘　　要：【目的】观察加味青娥丸联合温针灸治疗肾虚血瘀型绝经后骨量减少的临床疗效。【方法】将75例肾虚血瘀型绝经后骨量减少患者随机分为观察组38例和对照组37例。对照组给予温针灸联合碳酸钙维D3片口服治疗,观察组在对照组治疗的基础上给予加味青娥丸治疗。连续治疗12周。治疗12周后,评价2组临床疗效,观察2组患者治疗前后腰椎L1-L4骨密度(BMD),以及血清雌二醇(E2)、骨源性碱性磷酸酶(BALP)、骨钙素(OC)水平的变化情况,比较2组患者治疗前后中医证候评分与生活质量量表躯体健康总评(PCS)评分的变化情况。【结果】(1)研究过程中,观察组失访3例,对照组失访4例。最终观察组35例、对照组33例纳入疗效统计。(2)治疗后,2组患者的血清E2、BALP、OC及BMD均明显改善(P<0.05),且观察组在改善血清E2、BALP、OC及BMD方面均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的生活质量PCS评分及中医证候评分均明显改善(P<0.05),且观察组在改善生活质量PCS评分及中医证候评分方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)观察组总有效率为91.43%(32/35),对照组为72.73%(24/33)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(5)观察组不良反应发生率为8.57%(3/35),对照组为9.09%(3/33)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】加味青娥丸联合温针灸治疗肾虚血瘀型绝经后骨量减少,能明显改善患者的临床症状,提高患者的骨密度,从而提高患者的生活质量,并且不良反应少,疗效显著。Objective To observe the clinical effect of modified Qing’e Pills combined with moxibustion with warming needle in treating postmenopausal bone loss of kidney deficiency and blood stasis syndrome. Methods Seventy five cases of patients with postmenopausal bone loss of kidney deficiency and blood stasis syndrome were randomly divided into observation group(38 cases)and control group(37 cases). Both groups were treated with moxibustion with warming needle combined with oral use of calcium carbonate vitamin D3 tablets, while the observation group was given additional modified Qing’e Pills,and the treatment lasting 12 consecutive weeks.After 12 weeks of treatment,the clinical effect of the two groups was evaluated,and the changes of lumbar L1-L4 bone mineral density(BMD), serum estradiol(E2), serum bone derived alkaline phosphatase(BALP)and osteocalcin(OC)levels in the two groups were observed before and after treatment. The changes of traditional Chinese medicine(TCM)syndrome score and physical component summary(PCS)score of quality of life scale were compared between the two groups before and after treatment. Results(1)During the study,3 cases in the observation group and 4 cases in the control group were lost to follow up. Finally,35 cases in the observation group and 33 cases in the control group were included in the curative effect statistics.(2)After treatment,the serum E2,BALP,OC and BMD in the two groups were significantly improved(P<0.05),and the observation group was significantly superior to that of the control group in improving serum E2,BALP,OC and BMD,the difference being statistically significant(P<0.05).(3)After treatment,PCS score of quality of life and TCM syndrome score of the two groups were significantly improved(P<0.05),and the observation group was significantly better than the control group in improving PCS of quality of life score and TCM syndrome score, and the difference was statistically significant(P<0.05).(4)The total effective rate was 91.43%(32/35)in the observation group and72.73%

关 键 词：温针灸 加味青娥丸 绝经后骨量减少 肾虚血瘀型 骨密度 生活质量 临床观察 

分 类 号：R246.9[医药卫生—针灸推拿学]