庞龙治疗视网膜静脉阻塞用药规律的数据挖掘  

Data Mining of Medication Rules of Professor PANG Long for the Treatment of Retinal Vein Occlusion

作　　者：林婉儿 李昀熹 庞龙(指导)[2] LIN Wan-Er;LI Yun-Xi;PANG Long(The Second Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Dept.of Ophthalmology,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120 Guangdong,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510405 [2]广东省中医院眼科,广东广州510120

出　　处：《广州中医药大学学报》2021年第9期2003-2008,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】挖掘庞龙教授治疗视网膜静脉阻塞的组方用药规律。【方法】筛选2019年5月至2020年5月庞龙教授于广东省中医院眼科门诊及住院部治疗视网膜静脉阻塞有效医案的处方资料,建立视网膜静脉阻塞治疗方剂基本数据库。采用频次分析、关联规则分析和聚类分析等数据挖掘方法挖掘庞龙教授治疗视网膜静脉阻塞的组方用药规律。【结果】共筛选出庞龙教授治疗视网膜静脉阻塞方剂134首,涉及147味中药,用药频次达1 886次。频次分析结果显示,使用频次较高的中药为茯苓、甘草、三七、丹参、薏苡仁、党参、密蒙花、白术、枸杞子、白芍、五味子等,使用频率较高的药物类别为补虚药、清热药、活血化瘀药、止血药、利水渗湿药等。关联规则分析和聚类分析结果显示,得到79条关联规则和关联强度较强的药物组合31组,聚类分析得到6类。【结论】数据挖掘结果表明庞龙教授治疗视网膜静脉阻塞处方用药规律如下:首辨虚实,虚者益气养血、补益肝肾,实者利湿化痰、清热养血,虚实夹杂当分清主次,或补虚为主,或祛邪为主;通络、明目贯穿疾病始终。Objective To analyze the medication department and prescription rules for retinal vein occlusion(RVO)treated by Professor PANG Long. Methods The clinical data of the effective cases of RVO patients treated by Professor PANG Long from May 2019 to May 2020 in the outpatient department and inpatient department of ophthalmology of Guangdong Provincial Hospital of Traditional Chinese Medicine were collected and screened,and then the prescription database for RVO was established. Data mining methods such as frequency analysis,association rule analysis and clustering analysis were used to explore the medication and prescription rules for RVO. Results A total of 134 prescriptions involving 147 herbs were included, and the medication frequency arrived to 1 886 times. The frequency analysis results showed that the high-frequency herbs were Poria,Radix Glycyrrhizae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Codonopsis, Flos Buddlejae,Rhizoma Atractylodis Macrocephalae,Fructus Lycii,Radix Paeoniae Alba,and Fructus Schisandrae Chinensis. The high-frequency herbs were classified into the categories of tonic herbs,herbs for clearing heat,herbs for activating blood and resolving stasis,herbs for checking bleeding,and herbs for inducing diuresis and draining dampness. The results of association rule analysis and clustering analysis showed that 79 herbal combinations and 31 herbal pairs with high association coefficient were obtained,and the high-frequency herbs were clustered into 6 groups. Conclusion The data mining results indicated that the medication and prescription rules for RVO treated by Professor PANG Long are shown as the following:the deficiency syndrome and excess syndrome should be differentiated firstly,therapies of replenishing qi and nourishing blood,tonifying liver and kidney can be used for the RVO patients with the deficiency syndrome,therapies of eliminating dampness and resolving phlegm,clearing heat and nourishing blood can be used for the RVO patients with the excess syndrome,and f

关 键 词：视网膜静脉阻塞 益气养血 利湿化痰 通络 明目 用药规律 数据挖掘 庞龙 

分 类 号：R276.7[医药卫生—中医五官科学]