神经再生、多模态神经调制治疗脊髓损伤的研究进展  

Research progress of neuroregeneration and multimodal neuromodulation in the treatment of spinal cord injury

作　　者：冯浩铭 余珊子 张小波 冯万江 王剑龙[1] Feng Haoming;Yu Shanzi;Zhang Xiaobo;Feng Wanjiang;Wang Jianlong(Department of Spine Surgery,The Third Xiangya Hospital of Central South University,Changsha 410000,China;Department of Pain,The Third Xiangya Hospital of Central South University,Changsha 410000,China)

机构地区：[1]中南大学湘雅三医院脊柱外科,长沙410000 [2]中南大学湘雅三医院疼痛科,长沙410000

出　　处：《中国综合临床》2021年第5期474-479,共6页Clinical Medicine of China

摘　　要：脊髓损伤在临床上具有较高致残率,依据不同的损伤节段和严重程度可将其分为完全性脊髓损伤和不完全性脊髓损伤。治疗的主要目的是保护神经,目前急性脊髓损伤主要采用外科减压手术、神经营养、激素治疗、低温治疗以及康复干预等临床综合治疗。近年来内、外源性神经干细胞研究领域有所突破,干细胞移植的基础研究已取得重要进展。从长远来看,神经再生与神经调制措施可能是修复脊髓损伤最有前景的疗法。Spinal cord injury has a high rate of disability in clinical practice,which can be divided into complete SCI and incomplete SCI according to different injury segments and severity.The main purpose of treatment is to protect the nerves.At present,acute spinal cord injury is mainly treated with surgical decompression,neurotrophic treatment,hormone therapy,hypothermia therapy,rehabilitation intervention and other clinical comprehensive treatment.In recent years,breakthroughs have been made in the field of endogenous and exogenous neural stem cell research,and important progress has been made in the basic research of stem cell transplantation.In the long run,nerve regeneration and nerve modulation may be the most promising therapy for the repair of spinal cord injury.

关 键 词：脊髓损伤 神经再生 多模态神经调制 减压手术 激素疗法 治疗性低温 

分 类 号：R651.2[医药卫生—外科学]