苦参碱和氧化苦参碱对细菌性阴道炎的临床药理作用研究进展  

Research Progress on Clinical Pharmacologic Effects of Matrine and Oxymatrine in Prevention and Treatmet of Bacterial Vaginitis

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第7期936-940,共5页Anti-infection Pharmacy

摘　　要：苦参碱和氧化苦参碱具有广泛的生物活性,如保护心、肝、肺、肾、脑和血管的作用,对心脏有正性肌力、负性频率、抗心律失常的作用,其还有升高白细胞、平喘、抗溃疡、抗纤维、中枢神经药理作用(镇静、催眠、镇痛等),以及抗肿瘤、免疫调节、抗菌、抗病毒、抗寄生虫、抗炎等药理作用。在妇科治疗领域中,苦参碱和氧化苦参碱具有抗妇科肿瘤作用,能保护乳腺上皮细胞、子宫内膜上皮细胞和阴道上皮细胞的功能,还能对抗各种致病因子引起的上皮细胞炎性病变。临床上已将其用于治疗各种宫颈炎、阴道炎,也被试用于治疗乳腺癌、卵巢癌、宫颈癌和子宫内膜癌。文中综述苦参碱和氧化苦参碱防治细菌性阴道炎临床药理作用的文献资料,并对其研究进展做了分析。Matrine and oxymatrine have a widespread bioactivities, including protection of organs(heart, liver,lung, kidney, brain and blood vessel), positive inotropic action, negative chronotropic action, antiarrhythmia, the effect of increasing leukocyte, antiasthma, antiulcer, anti-fibrogenesis, the central nervous pharmacological action(sedation,hypnogenesis and analgesia), antitumor, immunoregulation, anti-bacteria, anti-virus, anti-parasite and anti-inflammation. In gynecologic domain, matrine and oxymatrine have the effects of anti-gynecologic tumors, and could protect epithelial cells of mamma, endometrium and vagina, and antagonize inflammatory pathologic change of epithelial cells induced by various pathogenic factors. In clinic matrine and oxymatrine have been used to treat various cervicitis and vaginitis,and have been tried to treat mammary cancer, ovarian carcinoma, cervical carcinoma and endometrial carcinoma.In this paper, the literatures on the clinical pharmacological effects of matrine and oxymatrine on the prevention and treatment of bacterial vaginitis have been reviewed, and their research progress has been analyzed.

关 键 词：苦参碱 氧化苦参碱 上皮细胞 阴道炎 药理作用 

分 类 号：R961[医药卫生—药理学]