Coronary vasospasm:A narrative review  

作　　者：Jacob Jewulski Sumesh Khanal Khagendra Dahal 

机构地区：[1]Foundational Medical Studies,Oakland University William Beaumont School of Medicine,Rochester,MI 48309,United States [2]Department of Internal Medicine,William Beaumont Hospital,Royal Oak,MI 48073,United States [3]Department of Cardiology,CHI Health,Creighton University School of Medicine,Omaha,NE 68118,United States

出　　处：《World Journal of Cardiology》2021年第9期456-463,共8页世界心脏病学杂志（英文版）（电子版）

摘　　要：Coronary artery vasospasm(CAVS)plays an important role in acute chest pain syndrome caused by transient and partial or complete occlusion of the coronary arteries.Pathophysiology of the disease remains incompletely understood,with autonomic and endothelial dysfunction thought to play an important role.Due to the dynamic nature of the disease,its exact prevalence is not entirely clear but is found to be more prevalent in East Asian and female population.Cigarette smoking remains a prominent risk factor,although CAVS does not follow traditional coronary artery disease risk factors.Many triggers continue to be identified,with recent findings identifying chemotherapeutics,allergens,and inflammatory mediators as playing some role in the exacerbation of CAVS.Provocative testing with direct visualization is currently the gold-standard for diagnosis,but non-invasive tests,including the use of biomarkers,are being increasingly studied to aid in the diagnosis.Treatment of the CAVS is an area of active research.Apart from risk factor modification,calcium channel blockers are currently the first line treatment,with nitrates playing an important adjunct role.High-risk patients with life-threatening complications should be considered for implantable cardioverter defibrillator(ICD),although timing criteria for escalated therapy require further investigation.The role of pharmaceuticals targeting oxidative stress remains incompletely understood.

关 键 词：Coronary artery vasospasm Vasospastic angina Prinzmetal angina Variant angina Coronary artery disease 

分 类 号：R543.3[医药卫生—心血管疾病]