Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review  

作　　者：Laura Coto Irati Mendia Carolina Sousa Julio César Bai Angel Cebolla 

机构地区：[1]Research and Development,Biomedal,Camas 41900,Seville,Spain [2]Human Nutrition and Food Science Doctoral Program,University of Granada,Granada 18011,Spain [3]Molecular Biology,Biomedicine and Clinical Research Doctoral Program,University of Seville,Seville 41012,Spain [4]Department of Microbiology and Parasitology,University of Seville,Seville 41013,Spain [5]Department of Gastroenterology,Dr.Carlos Bonorino Udaondo Gastroenterology Hospital,Buenos Aires 1264,Argentina [6]Research Institutes,Universidad del Salvador,Buenos Aires 1050,Argentina

出　　处：《World Journal of Gastroenterology》2021年第37期6306-6321,共16页世界胃肠病学杂志（英文版）

基　　金：Supported by Ministerio de Ciencia e Innovación,No.DI-16-08943 and No.DI-17-09627.

摘　　要：BACKGROUND Gluten is a complex mixture of proteins with immunogenic peptide sequences triggering the autoimmune activity in patients with celiac disease(CeD).Gluten immunogenic peptides(GIP)are resistant to gastrointestinal digestion and are then excreted via the stool and urine.Most common detection methods applied in the follow-up visits for CeD patients such as serology tests,dietetic interviews,questionnaires,and duodenal biopsy have been proved to be inefficient,invasive,or inaccurate for evaluating gluten-free diet(GFD)compliance.Determination of excreted GIP in stool and urine has been developed as a non-invasive,direct,and specific test for GFD monitoring.AIM To summarize published literature about the clinical utility of GIP determination in comparison to the tools employed for GFD monitoring.METHODS PubMed and Web of Science searches were performed using the keywords“gluten immunogenic peptides”or“gluten immunogenic peptide”and a combination of the previous terms with“feces”,“stools”,“urine”,“celiac disease”,“gluten-free diet”,and“adherence”to identify relevant clinical studies published in English and Spanish between 2012 to January 2021.Reference lists from the articles were reviewed to identify additional pertinent articles.Published articles and abstracts reporting the clinical use of GIP determination in stool and/or urine for the follow-up of patients with CeD in comparison with other tools in use were included.Case reports,commentaries,reviews,conference papers,letters,and publications that did not focus on the aims of this review were excluded.RESULTS Total of 15 publications were found that involved the use of GIP determination in stool and/or urine to monitor the adherence to the GFD in comparison to other tools.Studies included both children and adults diagnosed with CeD and healthy volunteers.Overall,these preliminary studies indicated that this novel technique was highly sensitive for the detection of GFD transgressions and therefore could facilitate the foll

关 键 词：Celiac disease Gluten-free diet Gluten immunogenic peptides Immunoassays STOOL URINE 

分 类 号：R597.8[医药卫生—内科学]