Empty nose syndrome pathogenesis and cell-based biotechnology products as a new option for treatment  

作　　者：Inna M Gordiienko Olga S Gubar Roman Sulik Taras Kunakh Igor Zlatskiy Alona Zlatska 

机构地区：[1]Biotechnology Laboratory,Medical Company“Good Cells”,Kyiv 03115,Ukraine [2]R.E.Kavetsky Institute of Experimental Pathology,Oncology and Radiobiology NAS of Ukraine,Kyiv 03022,Ukraine [3]Institute of Molecular Biology and Genetics NAS of Ukraine,Kyiv 03143,Ukraine [4]State Institute of Genetic and Regenerative Medicine,National Academy of Medical Sciences of Ukraine,Kyiv 04114,Ukraine

出　　处：《World Journal of Stem Cells》2021年第9期1293-1306,共14页世界干细胞杂志（英文版）（电子版）

摘　　要：Empty nose syndrome (ENS) is a rare complication that develops after partial orcomplete turbinectomy. The main feature of ENS is paradoxical nasal obstructionfeeling despite objectively wide nasal airway. ENS pathogenesis is multifactorialand includes changes in laminar physiological airflow, disruption of mucosafunctions and deficient neural sensation. This leads to the development of ENSsymptomatology such as dyspnea, nasal dryness, nasal burning, nasalobstruction, feeling of suffocation and even comorbid psychiatric disorders thatsignificantly impairs life quality. Specific effective treatment of ENS does not existup to date. In this review we outline existing biomaterial for surgical reconstitutionof nasal anatomy and discuss the perspective of stem cell-based technologiesin ENS management. The main focus is directed to justification ofrationality application of adult mesenchymal stem cells (MSCs) from differenttissues origin and neural crest-derived stem cells (NCSCs) based on their intrinsicbiological properties. MSCs transplantation may stimulate mucosa tissueregeneration via trophic factors secretion, direct transdifferentiation into epithelialcells and pronounced immunosuppressive effect. From the other hand, NCSCsbased on their high neuroprotective properties may reconstitute nerve structureand functioning leading to normal sensation in ENS patients. We postulate thatapplication of cell-based and tissue-engineered products can help to significantlyimprove ENS symptomatology only as complex approach aimed at reconstitutionof nasal anatomy, recovery the nasal mucosa functionality and neural tissuesensation.

关 键 词：Empty nose syndrome Stem-cell-based technologies Implants biomaterials GRAFTS HYDROGELS Mesenchymal stem cells 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]