稳定性冠状动脉粥样硬化性心脏病患者心室重构辅助性T细胞17/白细胞介素-17通路的变化及临床意义  

Changes of helper T lymphocyte/interleukin 17 pathway in ventricular remodeling in patients with stable coronary heart disease and its clinical significance

作　　者：王伟[1] 王文英[2] 赵新惠[1] 孟庆捷 田文婷[1] Wang Wei;Wang Wenying;Zhao Xinhui;Meng Qingjie;Tian Wenting(Department of Laboratory Medicine,Binzhou Central Hospital Binzhou 251700,China;Department of Cardiology,Binzhou Central Hospital,Binzhou 251700,China)

机构地区：[1]滨州市中心医院检验科,山东滨州251700 [2]滨州市中心医院心内科,山东滨州251700

出　　处：《中国临床实用医学》2021年第4期29-33,共5页China Clinical Practical Medicine

摘　　要：目的探究与分析稳定性冠状动脉粥样硬化性心脏病(CHD)患者心室重构辅助性T细胞(Th17)/白细胞介素-17(IL-17)通路的变化及临床意义。方法选取2020年5月至2021年5月滨州市中心医院心内科收治的66例稳定性CHD患者为稳定性CHD组,男37例,女29例,年龄(65.10±4.25)岁,年龄范围为54~71岁。选取同时期至滨州市中心医院健康体检的60名成年人为健康对照组,男35名,女25名,年龄(64.25±4.11)岁,年龄范围为55~72岁。回顾性分析两组纳入者的临床资料。观察比较两组纳入者外周血中Th17、IL-17的水平,心室重构相关临床指标,同时采用Spearman线性相关性检验,探讨心室重构指标与Th17及IL-17的相关性。结果稳定性CHD组外周血Th17[(1.57±0.20)%]及IL-17水平[(12.89±3.15)pg/ml]均高于健康对照组[(1.24±0.23)%,(10.22±2.23)pg/ml],差异有统计学意义(P<0.05)。稳定性CHD组平均室壁应力[(975.33±90.66)mg]、左心室心肌质量指数[(2.42±0.43)mg/g]、左心室收缩末期容积[(55.64±4.29)ml]及舒张末期容积[(152.60±14.33)ml]均高于健康对照组[(852.36±84.63)mg、(1.96±0.35)mg/g、(39.64±5.25)ml、(112.77±14.21)ml],左心室射血分数[(53.11±10.43)%]低于健康对照组[(78.62±10.25)%],差异有统计学意义(P<0.05)。行Spearman线性相关性检验分析可见,Th17、IL-17与平均室壁应力、左心室心肌质量指数、左心室收缩末期容积、舒张末期容积均呈显著的正相关性,与左心室射血分数呈显著的负相关性(P<0.05)。结论Th17及IL-17在稳定性CHD患者中可表现出较高的表达水平,能够用于促进心室重构的发生及发展。Objective To explore and analyze the changes and clinical significance of helper T lymphocyte(Th17)/interleukin 17(IL-17)pathway in ventricular remodeling in patients with stable coronary heart disease.Methods There were sixty-six patients with stable coronary heart disease admitted to the cardiology of Binzhou Central Hospital from May 2020 to May 2021 were selected as the stable coronary heart disease group,with 37 males and 29 females,aged(65.10±4.25)years old,ranging form 54 to 71 years old.There were sixty adults who had a physical examination at Binzhou Central Hospital during the same period were selected as the healthy control group,with 35 males and 25 females,aged(64.25±4.11)years old,ranging form 55 to 72 years old.The clinical data of the two groups of subjects were retrospectively analyzed.The levels of Th17 and IL-17 in the peripheral blood of the two groups of subjects were observed and compared,and the clinical indicators related to ventricular remodeling were observed.At the same time,the Spearman linear correlation test was used to explore the correlation between ventricular remodeling indicators and Th17 and IL-17.Results Peripheral blood Th17[(1.57±0.20)%]and IL-17 levels[(12.89±3.15)pg/ml]in the stable coronary heart disease group were higher than those in the healthy control group[(1.24±0.23)%,(10.22±2.23)pg/ml],the difference was statistically significant(P<0.05).The average wall stress of the stable coronary heart disease group[(975.33±90.66)mg],left ventricular myocardial mass index[(2.42±0.43)mg/g],left ventricular end systolic volume[(55.64±4.29)ml]and end diastole The volume[(152.60±14.33)ml]is higher than that of the healthy control group[(852.36±84.63)mg,(1.96±0.35)mg/g,(39.64±5.25)ml,(112.77±14.21)ml],left ventricular injection The blood score[(53.11±10.43)%]was lower than that of the healthy control group[(78.62±10.25)%],the difference was statistically significant(P<0.05).Spearman linear correlation test analysis showed that Th17 and IL-17 were significantly positi

关 键 词：稳定性冠状动脉粥样硬化性心脏病 心室重构 辅助性T细胞/白细胞介素-17通路 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]