系统性红斑狼疮患者抗核抗体的表达及临床表现分析  

Expression of Antinuclear Antibody and Clinical Manifestation in Patients with Systemic Lupus Erythematosus

作　　者：邹红云[1] 晁亚妮 白文栋 何江[1] Zou Hongyun;Chao Yani;Bai Wendong;He Jiang(Department of Clinical Laboratory, General Hospital of Xinjiang Military Command, Urumqi 830000, China)

机构地区：[1]新疆军区总医院检验科,乌鲁木齐830000

出　　处：《成都医学院学报》2021年第5期591-594,598,共5页Journal of Chengdu Medical College

基　　金：新疆维吾尔自治区自然科学基金面上项目(No:2016D01C394)。

摘　　要：目的探讨系统性红斑狼疮(SLE)患者抗核抗体(ANA)表达及首发临床表现在不同性别、年龄的分布特点。方法选取2015年1月至2018年12月在新疆军区总医院住院并确诊的263例SLE患者为研究对象,对患者年龄、性别、起病时首发临床表现、ANA及荧光核型实验结果等进行比较。结果SLE患者ANA阳性率为94.29%,在不同性别、年龄组间ANA阳性率比较,差异无统计学意义(P>0.05)。ANA免疫荧光核型以核颗粒型最为多见(64.64%),两种核型(核颗粒和着丝点)阳性率在不同年龄组间差异有统计学意义(P<0.05)。女性患者Ro-52和NUC抗体阳性率均明显高于男性(P<0.05)。抗组蛋白抗体(HI)阳性率在不同年龄组比较,差异有统计学意义(P<0.05)。SLE患者首发临床表现中肾损害发生率最高,其次为皮肤损害和关节炎。男性患者皮肤损害和神经系统症状的发生率明显高于女性,但关节炎发生率明显低于女性(P<0.05)。结论SLE患者ANA核型、ANA谱和首发临床表现分布具有性别和年龄差异,其ANA表达和临床表现分布特点可为SLE的早期诊断和治疗提供重要参考依据。Objective To analyze the specificities of the expression of antinuclear antibody(ANA)and initial clinical manifestations among different gender and age groups in patients with systemic lupus erythematosus(SLE).Methods A total of 263 SLE patients hospitalized in General Hospital of Xinjiang Military Command from January 2015 to December 2018 were enrolled.The clinical data of the patients,including age,gender,initial clinical manifestations,ANA and immunofluorescent pattern,were statistically analyzed and compared.Results The positive rate of ANA in SLE patients was 94.29%,and there was no significant difference in the positive rate of ANA among different gender and age groups(P>0.05).The most common ANA immunofluorescence karyotype was nuclear speckled pattern(64.64%).There was statistical significance in the positive rates of nuclear speckled pattern and centromere pattern among different age groups(P<0.05).The positive rates of Ro-52 and NUC antibodies in female patients were significantly higher than those in male patients(P<0.05).There was statistical significance in the positive rate of anti-histone(HI)antibody among different age groups(P<0.05).The incidence of renal damage was the highest among the initial clinical manifestations of SLE,followed by skin damage and arthritis.Compared with female patients,male patients had higher incidence of skin lesions and neurological symptoms but lower incidence of arthritis(P<0.05).Conclusion The distribution of ANA karyotypes,ANA profiles and initial clinical manifestations in SLE patients differed by sex and age.The distribution of ANA expression and clinical manifestations in SLE patients can provide important reference for the early diagnosis and treatment of SLE.

关 键 词：系统性红斑狼疮 抗核抗体 免疫荧光核型 临床表现 

分 类 号：R593.241[医药卫生—内科学]