三金排石颗粒治疗输尿管中下段结石临床疗效观察  

Clinical Observation of Sanjin Paishi Granules in the Treatment of Calculi in the Middle-lower Ureter

作　　者：林谋清[1] 蔡泽锋[1] 苏蕴瑜 LIN Mou-Qing;CAI Ze-Feng;SU Yun-Yu(Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510030 Guangdong,China)

机构地区：[1]广东省第二中医院,广东广州510030

出　　处：《广州中医药大学学报》2021年第10期2089-2096,共8页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20181030)。

摘　　要：【目的】探讨三金排石颗粒对输尿管中下段结石的临床治疗效果。【方法】将165例输尿管中下段结石患者随机分为试验组、尿石通组和安慰剂组,每组各55例。3组患者均给予大量饮水,并配合跑步、跳跃运动的常规治疗,在此基础上,试验组给予口服三金排石颗粒治疗,尿石通组给予口服尿石通丸治疗,安慰剂组给予口服安慰剂治疗,疗程为12周。观察3组患者治疗前后尿白细胞(WBC)、尿红细胞(RBC)、全血WBC、C反应蛋白(CRP)、血肌酐(Cr)、血尿素氮(BUN)、肾绞痛视觉模拟量表(VAS)评分的变化情况,并比较3组患者的临床疗效、排石时间及复发率。【结果】(1)研究过程中,试验组脱落2例,尿石通组脱落5例,安慰剂组脱落3例;最终纳入155例,其中试验组53例,尿石通组50例,安慰剂组52例。(2)疗效方面,治疗12周后,试验组的总有效率为88.68%(47/53),尿石通组为72.00%(36/50),安慰剂组为57.69%(30/52)。组间比较,试验组的疗效明显优于尿石通组和安慰剂组,而尿石通组又明显优于安慰剂组,差异均有统计学意义(P<0.05)。(3)治疗后,3组患者的尿WBC、尿RBC、全血WBC、CRP、肾绞痛VAS评分均较治疗前明显下降,差异均有统计学意义(P<0.01);而血Cr、BUN较治疗前虽有所下降,但差异无统计学意义(P>0.05)。组间差值比较,试验组对尿WBC、尿RBC、全血WBC、CRP、肾绞痛VAS评分的改善作用均明显优于尿石通组和安慰剂组,差异均有统计学意义(P<0.05或P<0.01);而3组血Cr、BUN差值比较,差异均无统计学意义(P>0.05)。(4)排石时间方面,试验组的排石时间较尿石通组和安慰剂组明显缩短,而尿石通组又较安慰剂组明显缩短,差异均有统计学意义(P<0.05)。(5)复发率方面,试验组的复发率为36.36%(8/22),尿石通组为53.85%(7/13),安慰剂组为62.50%(5/8)。组间比较,试验组的复发率明显低于尿石通组和安慰剂组,而尿石通组又明显低于安慰剂组,差Objective To investigate the clinical therapeutic effect of Sanjin Paishi Granules on the calculi in the middle-lower ureter.Methods A total of 165 patients with calculus in the middle-lower ureter were randomly divided into trial group,Niaoshitong group and placebo group,55 patients in each group.All of the patients in the 3 groups were inquired to drink plenty of water and take running and jumping exercises.And additionally,the trial group was given oral use of Sanjin Paishi Granules,Niaoshitong group was given oral use of Niaoshitong Pills,and the placebo group was given oral use of placebo,the course lasting for 12 weeks.The changes in the levels of urine white blood cell(WBC),urine red blood cell(RBC),whole blood WBC,C-reactive protein(CRP),blood creatinine(Cr),and blood urea nitrogen(BUN),as well as the visual analog scale(VAS)scores of renal colic in the 3 groups were observed before and after treatment.Meanwhile,the clinical efficacy,calculus removal time and recurrence rate of the 3 groups were compared.Results(1)During the trial,2 cases fell off the trial group,5 cases fell off the Niaoshitong group and 3 cases fell off the placebo group.At the end of trial,a total of 155 patients were involved,including 53 from the trial group,50 from the Niaoshitong group,and 52 from the placebo group.(2)In terms of curative effect,after 12 weeks of treatment,the total effective rate of the trial group was 88.68%(47/53),and that of the Niaoshitong group and the placebo group was 72.00%(36/50),57.69%(30/52)respectively.The intergroup comparison showed that the efficacy of the trial group was significantly superior to that of the Niaoshitong group and the placebo group,and the efficacy of Niaoshitong group was significantly superior to that of the placebo group,the differences being statistically significant(P<0.05).(3)After treatment,urinary WBC,urinary RBC,whole blood WBC,CRP and VAS scores of renal colic in the 3 groups were significantly decreased compared with those before treatment,and the differences were statist

关 键 词：三金排石颗粒 输尿管中下段结石 尿石通丸 排石时间 血尿 

分 类 号：R693.4[医药卫生—泌尿科学]