可控药物释放输送系统研究进展  

Advances and perspectives in controlled drug delivery systems

作　　者：曾云 林莉莉 刘刚[2] ZENG Yun;LIN Li-li;LIU Gang(Department of Pharmacology,Xiamen Medical College,Xiamen 361009;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,Xiamen University,Xiamen 361102,Fujian,China)

机构地区：[1]厦门医学院药理学教研室,福建厦门361009 [2]厦门大学分子影像暨转化医学研究中心,福建厦门361102

出　　处：《川北医学院学报》2021年第9期1129-1133,共5页Journal of North Sichuan Medical College

基　　金：国家自然科学基金(81801817);福建省教育厅中青年教师教育科研项目(JT180649);福建省大学生创新创业训练计划项目(201812631010);厦门医学院呼吸疾病研究所科研平台开放课题(校20190267)。

摘　　要：新型药物输送系统可增强药物体内稳定性、控制药物释放等提高药物治疗特异性,降低药物毒副作用。近年来,药物智能控释技术已取得重大进展,新兴治疗药物(如生物制剂)、给药方式需求(如口服的延长药物释放微型装置和可注射特殊医用材料)及保护敏感药物分子的先进载药系统等可有效提升疾病防治水平。基于纳米囊泡、病原体仿生载体和工程化改造细胞(如特异性靶向、延长循环时间和免疫逃逸)的可控释放载药体系具有良好的应用前景。本文综述了药物输送系统设计的指导性原则及其控释机制,系统阐述了注射性药物递送系统、口服药物递送系统及生物源仿生药物递送系统研究前沿和进展。Advanced drug delivery systems can improve the specificity of drug therapy and reduce toxic side effects by enhancing the stability of drugs in vivo and controlling the release.In recent years,significant advances have been made in intelligent controlled release drug technologies,with emerging therapeutic drugs(e.g.biologics),drug delivery methods(e.g.micro-devices for prolonged drug release that can be taken orally and unique injectable medical materials),and advanced drug delivery systems that protect sensitive drug molecules that can effectively enhance disease prevention and treatment.Controlled drug delivery systems based on nano-vesicles,pathogenic biomimetic carriers,and bio-engineered cells(e.g.specific targeting,extended circulation,and immune escape)also have promising applications.In this paper,we reviewed the principles for the design of drug delivery systems and the mechanisms of controlled release.We systematically described the frontiers and advances in the research of injectable drug delivery systems,oral drug delivery systems,and biogenic biomimetic drug delivery systems.

关 键 词：药物控释 纳米药物 微环境响应 药物研发 生物医用材料 

分 类 号：R452[医药卫生—治疗学] R96[医药卫生—临床医学]