普外科脓毒症患者血清新喋呤水平与临床预后的关系  

Correlation of serum level of neopterin and clinical prognosis in septic patients in general surgery

作　　者：周皓岚[1,2] 付英[1] 黄元庆[2] ZHOU Hao-lan;FU Ying;HUANG Yuan-qing(Department of General Surgery,Bazhong Hospital of Traditional Chinese Medicine,Bazhong 636000,Sichuan,China;Intensive Care Unit,Bazhong Hospital of Traditional Chinese Medicine,Bazhong 636000,Sichuan,China)

机构地区：[1]巴中市中医院普外科,四川巴中636000 [2]巴中市中医院重症医学科,四川巴中636000

出　　处：《川北医学院学报》2021年第9期1192-1195,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨新喋呤在普外科脓毒症患者中的表达水平及其与临床预后的关系。方法:选择174例感染患者为研究对象,按是否患脓毒症分为脓毒症组(n=73)和非脓毒症组(n=101)。比较两组患者血清新喋呤水平、血常规及生化指标,分析各指标与临床预后的关系。结果:与非脓毒症组比较,脓毒症组WBC、NEU、血糖、ALT、CRP、PCT、Crea及新喋呤水平增高(P<0.05)。脓毒症组血清新喋呤水平与WBC、NEU、Crea、CRP、PCT和SOFA评分呈正相关(P<0.05)。脓毒症组以血清新喋呤水平≥83.1 nmol/L为诊断界值,预测脓毒症30 d内死亡的ROC曲线下AUC为0.688(P=0.023)。回归分析显示,年龄≥60岁(r=2.236,P=0.038)、新喋呤≥83.1 nmol/L(r=3.464,P=0.017)及SOFA≥3(r=3.793,P=0.014)是脓毒症30 d内死亡的独立危险因素。结论:普外科感染患者中,血清新呤水平在脓毒症患者中增高,且与炎症反应、肾脏受损及临床病情严重程度呈正相关,≥83.1 nmol/L的脓毒症患者住院30 d死亡率增加。Objective:To explore the serum level of neopterin in sepsis in general surgery department and its associations with clinical prognosis.Methods:A total of 174 patients with infection-induced sepsis were divided into sepsis group(n=73)and non sepsis group(n=101).Serum concentration of,blood routine and biochemical parameters were assessed between the two groups,then correlations between serum neopterin and these parameters were studied.Results:The serum level of WBC,NEU,glucose,ALT,CRP,PCT,Crea,and neopterin in sepsis group were higher than those in non sepsis group(P<0.05).The serum neopterin level in sepsis group was positively correlated with WBC,NEU,Crea,CRP,PCT,and SOFA score(P<0.05).The ROC curve revealed an area under the curve(AUC)of 0.688(P=0.023)for predicting 30 d mortality with serum level of neopterin≥83.1 nmol/L.In the Cox regression analysis,age≥60 years(r=2.236,P=0.038),serum level of neopterin≥83.1 nmol/L(r=3.464,P=0.017),and SOFA≥3(r=3.793,P=0.014)were independent risk factors of 30 d hospital mortality.Conclusion:The level of serum neopterin in patients with infection-induced sepsis in general surgery department is elevated,and is positively associated with inflammatory response,kidney injury,and severity of disease.Serum neopterin≥83.1 nmol/L is an independent risk factor of 30 d in-hospital mortality for sepsis.

关 键 词：新喋呤 普外科 感染 脓毒 

分 类 号：R631[医药卫生—外科学]