潮气肺功能舒张试验及哮喘预测指数在0~3岁婴幼儿喘息性疾病中的作用  

Bronchodilation test of tidal breathing lung function test and asthma prediction index in children 0-3 years old with wheezing diseases

作　　者：黄建梅[1] 王桂兰[1] 骆国青 王冰洁[1] 刘翔腾[1] 黄娟[1] 林嘉镖[1] HUANG Jian-mei;WANG Gui-lan;LUO Guo-qing(Pediatric respiratory department of Zhangshan Bo'ai Hospital,Zhongshan 52840,China)

机构地区：[1]广东省中山市博爱医院小儿呼吸科,广东中山528400

出　　处：《吉林医学》2021年第10期2326-2328,共3页Jilin Medical Journal

基　　金：广东省中山市卫生和计划生育局医学科研项目[项目编号:2018J103];广东省中山市科技局社会公益科技研究专项基金资助课题[项目编号:2017B1012]。

摘　　要：目的:探讨潮气肺功能舒张试验结合哮喘预测指数在喘息患儿早期诊断、早期规范化治疗中的意义。方法:将2018年3~9月于中山市博爱医院住院、年龄为0~3岁、首次诊断为婴幼儿喘息的患儿根据哮喘预测指数分为API阳性组35例和API阴性组35例,选取同期住院的年龄为0~3岁、首次诊断为普通呼吸道感染不伴有喘息的患儿35例作为对照组。各组均进行潮气肺功能检测,吸入支气管舒张剂15 min后行支气管舒张试验,对比各组患儿用药前后肺功能指标。结果:API阳性组Vt、RR、TPTEF/TE、VPTEF/VE均较API阴性组及对照组低,对照组Vt、RR、TPTEF/TE、VPTEF/VE均高于API阴性组,各组之间Vt、RR、TPTEF/TE、VPTEF/VE比较,差异有统计学意义(P<0.05)。吸入支气管舒张剂后,API阳性组及API阴性组Vt、RR、TPTEF/TE、VPTEF/VE与用药前比较,差异有统计学意义(P<0.05)。对照组用药前与用药后比较,各指标差异均无统计学意义(P>0.05)。结论:API阳性患儿气道阻塞严重程度较API阴性患儿更重,支气管舒张剂在API阳性患儿中应用效果更佳。API联合潮气肺功能舒张试验能减少婴幼儿喘息性疾病的过度治疗,能为婴幼儿喘息性疾病的早期诊断及规范治疗提供依据。Objective To explore the significance of bronchodilation test combined with asthma prediction index in the early diagnosis and early standardized treatment of asthmatic children.Method From March 2018 to September 2018,children aged 0~3 years who were admitted to our hospital for the first diagnosis of infant wheeze were divided into API positive group 35 cases and API negative group 35 cases according to the asthma prediction index.A total of 35 children aged 0-3 years who were admitted to our hospital at the same time and were first diagnosed with common respiratory tract infection without wheezing were selected as the control group.Tidal breath pulmonary function was detected in each group,and bronchodilatation test was performed 15 minutes to compare the lung function indexes before and after medication in each group.Results Vt,RR,TPTEF/TE and VPTEF/VE in the API positive group were lower than those in the API negative group and the control group.Vt,RR,TPTEF/TE and VPTEF/VE were higher in the control group than in the observation group.The differences in Vt,RR,TPTEF/TE,and VPTEF/VE between each group were statistically significant(P<0.05).After inhaling bronchodilator,there were statistically significant differences in TPTEF/TE and VPTEF/VE in the API positive group and the API negative group compared with before administration(P<0.05).There were also statistical differences between the API positive group and the API negative group before and after Vt and RR administration(P<0.05).There was no statistical difference between the control group before and after medication(P>0.05).Conclusion The airway obstruction in API positive children is more serious than that in API negative children.The effect of bronchodilator is better in children with positive API.The combination of API and lung dilation test can reduce the overtreatment of wheezing disease in infants and provide a basis for the early diagnosis and standard treatment of wheezing disease in infants and young children.

关 键 词：婴幼儿喘息性疾病 哮喘预测指数 潮气呼吸肺功能舒张试验 

分 类 号：R725.6[医药卫生—儿科]