单剂与重复注射左西孟旦治疗急性心肌梗死合并心力衰竭患者的疗效评估  

Single dose and repeated injection of Levosimendan in treatment of acute myocardial infarction efficacy evaluation in patients with complicated heart failure

作　　者：吴彩云[1] 黄艳[1] 雷平平 Wu Caiyun;Huang Yan;Lei Pingping(The First People's Hospital of Fuzhou City,Fuzhou,Jiangxi 344000)

机构地区：[1]抚州市第一人民医院,江西抚州344000

出　　处：《基层医学论坛》2021年第28期4010-4012,共3页The Medical Forum

基　　金：抚州市指导性科技计划项目[(2019)4号序列号32]。

摘　　要：目的评估单剂与重复注射左西孟旦治疗急性心肌梗死合并心力衰竭患者的疗效。方法选取抚州市第一人民医院2018年5月-2021年3月期间收治的急性心肌梗死合并心力衰竭患者80例,随机分为对照组和观察组。对照组单次给予左西孟旦进行治疗,观察组重复给予左西孟旦治疗,对比2组治疗效果。结果2组治疗前左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)、左心室射血分数(LVEF)差异无统计学意义(P>0.05);治疗后观察组LVESV、LVEDV低于对照组,且LVEF高于对照组,差异有统计学意义(P<0.05)。2组治疗前N末端B型脑钠肽前体(NT-pro BNP)、去甲肾上腺素(NE)水平差异无统计学意义(P>0.05);治疗后观察组NT-pro BNP、NE水平均低于对照组,差异有统计学意义(P<0.05)。2组治疗前高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)相关炎性指标水平差异无统计学意义(P>0.05);治疗后2组各项炎性指标水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论重复注射左西孟旦治疗急性心肌梗死合并心力衰竭的效果优于单剂给药,更具推广价值。Objective To evaluate the efficacy of single dose versus repeated injection of levosimendan in patients with acute myocardial infarction complicated with heart failure.Methods Eighty patients with acute myocardial infarction complicated with heart failure admitted to our hospital from May 2018 to March 2021 were selected and divided into control group and observation group according to different research methods.The control group was given levosimendan once for treatment,and the observation group was repeatedly given levosimendan for treatment.The effects of single dose and repeated injection of levosimendan on patients with acute myocardial infarction complicated with heart failure were analyzed.Results There were no significant differences in left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV)and left ventricular ejection fraction(LVEF)between the two groups before treatment(P>0.05).After treatment,LVESV and LVEDV of the observation group were lower than those of the control group,and LVEF of the observation group was higher than that of the control group,with statistical significance(P<0.05).After treatment,LVESV and LVEDV in both groups were lower than before,and LVEF was higher than before(P<0.05).There were no significant differences in the levels of N-terminal B-type brain natriuretic peptide precursor(NT-pro BNP)and norepinephrine(NE)between the two groups before treatment(P>0.05).After treatment,the levels of NT-Pro BNP and NE in the observation group were lower than those in the control group,with statistical significance(P<0.05).There were statistically significant differences between the two groups before and after NT-Pro BNP treatment(P<0.05).Before treatment,there were no significant differences in the levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)related inflammatory indexes between the two groups(P>0.05).After treatment,the levels of inflammatory indexes in both groups were lower than before treatme

关 键 词：急性心肌梗死 心力衰竭 左西孟旦 单剂 重复注射 疗效 

分 类 号：R4[医药卫生—临床医学]