合成大麻素类新精神活性物质4F-MDMB-BUTINACA和MDMB-4en-PINACA的检测  

Identification of Synthetic Cannabinoid New Psychoactive Substances 4F-MDMBBUTINACA and MDMB-4en-PINACA

作　　者：王跨陡 袁晓亮 张玉荣[1] 胡钧健 曹芳琦 陈永生[1] WANG Kua-dou;YUAN Xiao-liang;ZHANG Yu-rong;HU Jun-jian;CAO Fang-qi;CHEN Yong-sheng(Institute of Forensic Science,Shanghai Public Security Bureau,Shanghai 200083,China;Shanghai Research Institute of Criminal Science and Technology,Shanghai 200083,China)

机构地区：[1]上海市公安局物证鉴定中心,上海200083 [2]上海市刑事科学技术研究院,上海200083

出　　处：《法医学杂志》2021年第4期505-510,共6页Journal of Forensic Medicine

基　　金：国家自然科学基金青年科学基金资助项目(81701864);上海市优秀学术带头人计划资助项目(19XD1432700);上海市青年科技启明星计划资助项目(18QB1403400);上海市自然科学基金探索类项目(17ZR1441600)。

摘　　要：目的建立联合傅里叶变换红外光谱(Fourier transform infrared spectrum,FTIR)、气相色谱-质谱(gas chromatography-mass spectrometry,GC-MS)、高分辨质谱和核磁共振波谱(nuclear magnetic resonance spectroscopy,NMR)多种技术鉴定可疑未知物的方法。方法对实际案件中缴获的可疑检材(灰白色粉末和黄色晶体)分别采用FTIR、GC-MS(溶剂为甲醇)、高分辨质谱(溶剂为甲醇)及NMR(溶剂为氘代甲醇)方法进行检测。结果GC-MS测得样品中主要组分的质谱特征离子m/z分别为219(基峰)、363、307、304、275、145、131和213(基峰)、357、301、298、269、185、171、145、131,高分辨质谱实测的精确质量数[M+H]+分别为364.20361和358.21234。经查阅资料和数据库检索比对再结合红外分析和质谱数据分析,可判断未知样品为合成大麻素类新精神活性物质2-[1-(4-氟丁基)-1H-吲唑-3-甲酰氨基]-3,3-二甲基丁酸甲酯(4F-MDMB-BUTINACA)和3,3-二甲基-2-[1-(4-戊烯-1-基)-1H-吲唑-3-甲酰氨基]丁酸甲酯(MDMB-4en-PINACA),并采用1H-NMR对其结构进行了确证。结论建立的多技术联合鉴定方法能用于未知样品中4F-MDMB-BUTINACA和MDMB-4en-PINACA的鉴定。该方法快速、方便、准确、可靠、实用,能够对今后涉及此类物质的案件鉴定提供参考依据。Objective To establish a method that combines a series of techniques including Fourier transform infrared spectrum(FTIR),gas chromatography-mass spectrometry(GC-MS),high resolution mass spectrometry and nuclear magnetic resonance spectroscopy(NMR)for identification of unknown substances.Methods The unknown samples(off-white powder and yellow crystal)seized in the actual cases were detected by FTIR,GC-MS(methanol as solvent),high resolution mass spectrometry(methanol as solvent)and NMR(deuterated methanol as solvent).Results The mass spectrum characteristic ions m/z of the main components in the samples measured by GC-MS were 219(base peak),363,307,304,275,145,131 and 213(base peak),357,301,298,269,185,171,145 and 131,respectively.The accurate mass numbers[M+H]+measured by high resolution mass spectrometry were 364.20361 and 358.21234,respectively.The unknown samples were identified as synthetic cannabinoid new psychoactive substances 4F-MDMB-BUTINACA and MDMB-4en-PINACA after data consultation and database retrieval and comparison,combined with infrared analysis and mass spectrometry data analysis,and their structures were confirmed by 1H-NMR.Conclusion The established multi-technology joint identification method can be used to identify 4F-MDMB-BUTINACA and MDMB-4en-PINACA in unknown samples.This method is fast,convenient,accurate,reliable and practical,and can provide reference for the identification of cases involving such substances in the future.

关 键 词：法医学 毒物分析 新精神活性物质 傅里叶变换红外光谱 气相色谱-质谱法 高分辨质谱法 核磁共振波谱法 合成大麻素 

分 类 号：DF795.1[医药卫生—法医学]