重组人生长激素对卵巢低反应患者IVF-ET临床结局的影响  

Effect of recombinant human growth hormone on IVF-ET outcome in patients with poor ovarian response

作　　者：周静[1] 王华伟[1] 饶猛 莫晖 苏梦驰 唐莉[1] ZHOU Jing;WANG Hua-wei;RAO Meng;MO Hui;SU Meng-chi;TANG Li(The First Affiliated Hospital of Kunming Medical University,Kunming 650000)

机构地区：[1]昆明医科大学第一附属医院生殖科,昆明650000

出　　处：《生殖医学杂志》2021年第10期1307-1311,共5页Journal of Reproductive Medicine

摘　　要：目的探讨重组人生长激素(rh-GH)对卵巢低反应(POR)患者行体外受精-胚胎移植(IVF-ET)鲜胚移植结局的影响。方法回顾性分析2019年1月至2020年6月在我院生殖科行拮抗剂方案促排卵后鲜胚移植的138例POR患者的临床资料。根据启动促排卵时是否添加rh-GH分为rh-GH组(n=70)和对照组(未添加rh-GH,n=68),比较两组患者的基本资料、促排卵情况、胚胎移植及临床结局的差异。结果两组患者的平均年龄、体质量指数(BMI)以及基础激素水平均无显著性差异(P>0.05)。rh-GH组患者的Gn总用量[(2425.00±717.92)U vs.(2767.14±1078.12)U]、Gn天数[(8.75±1.98)d vs.(9.60±2.48)d]及HCG日FSH水平[(17.16±4.81)U/L vs.(20.76±6.85)U/L]显著低于对照组(P<0.05);而获卵总数[(4.09±2.67)vs.(3.26±2.33)]、正常受精数[(3.40±2.18)vs.(2.54±2.16)]、胚胎种植率(38.71%vs.13.64%)及临床妊娠率(47.22%vs.20.69%)均显著高于对照组(P<0.05)。两组在HCG日雌、孕激素水平及LH水平、可利用胚胎数、优胚数及鲜胚移植率方面均无显著差异(P>0.05)。结论POR患者采用拮抗剂方案行IVF-ET鲜胚移植助孕时添加rh-GH有助于改善卵巢反应性和临床结局。Objective:To investigate the effect of recombinant human growth hormone(rh-GH)on the IVF-ET outcome of the fresh embryo transfer cycles in the patients with poor ovarian response(POR).Methods:The clinical data of 138 POR patients who received fresh embryo transfer in our reproductive center from Jan.2019 to Jun.2020 were retrospectively analyzed.According to whether rh-GH was added during ovulation induction,the patients were divided into rh-GH group(n=70)and control group(without rh-GH,n=68).The basic data,ovulation induction,embryo transfer and clinical outcomes of the two groups were compared.Results:There were no significant differences in mean age,body mass index(BMI)and basic hormone level between the two groups(P>0.05).The total doses of Gn[(2425.00±717.92)U vs.(2767.14±1078.12)U]and duration of Gn[(8.75±1.98)days vs.(9.60±2.48)days],serum FSH levels on HCG day[(17.16±4.81)U/L vs.(20.76±6.85)U/L]in the rh-GH group were significantly lower than those in the control group(P<0.05).The total number of oocytes retrieved[(4.09±2.67)vs.(3.26±2.33)],number of normal fertilization[(3.40±2.18)vs.(2.54±2.16)],embryo implantation rate(38.71%vs.13.64%)and clinical pregnancy rate(47.22%vs.20.69%)in the rh-GH group were significantly higher than those in the control group(P<0.05).There were no significant differences in the serum levels of E 2,progesterone and LH on HCG day,available embryo number,number of good quality embryos and fresh embryo transfer rate between the two groups(P>0.05).Conclusions:The addition of rh-GH during IVF-ET fresh embryo transfer cycle in the POR patients is helpful to improve the ovarian response and clinical outcome.

关 键 词：生长激素 卵巢低反应 体外受精-胚胎移植 

分 类 号：R711.6[医药卫生—妇产科学]