N6-甲基腺苷修饰在卵母细胞发育过程中作用机制的研究进展  

Research progress on mechanisms of N6-methyladenosine modification in oocyte development

作　　者：李艳梅[1,2,3] 王乃辉 孙小燕 张学红 LI Yan-mei;WANG Nai-hui;SUN Xiao-yan;ZHANG Xue-hong(The First Hospital of Lanzhou University,Lanzhou 730000;The First Clinical Medical College of Lanzhou University,Lanzhou 730000;Key Laboratory for Reproductive Medicine&Embryo of Gansu Province,Lanzhou 730000)

机构地区：[1]兰州大学第一医院,兰州730000 [2]兰州大学第一临床医学院,兰州730000 [3]甘肃省生殖医学与胚胎重点实验室,兰州730000

出　　处：《生殖医学杂志》2021年第10期1388-1392,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金(81960273)。

摘　　要：N6-甲基腺苷(m^(6)A)修饰是真核生物RNA中最普遍的一种表观遗传修饰,以一种动态、可逆的方式调节细胞内mRNA的甲基化水平。它由甲基转移酶、去甲基酶和甲基结合蛋白动态可逆调节。m^(6)A修饰在哺乳动物的配子发生、合子形成及胚胎发育过程中都表现出重要的调控作用。本文主要就m^(6)A甲基转移酶、去甲基酶和甲基结合蛋白各组成成员在卵母细胞发育过程中所起的作用及作用机制进行综述。N6-methyladenosine(m^(6)A)is the most common epigenetic modification in eukaryotic RNA,and regulates the methylation level of intracellular mRNA in a dynamic and reversible manner.It is regulated dynamically and reversibly by m^(6)A methyltransferase,demethylase and methyl binding protein.Recent studies have shown that m^(6)A modification plays an important regulatory role in mammalian gametogenesis,zygote formation and embryonic development.In this paper,the roles and mechanisms of the components of m^(6)A including methyltransferase,demethylase and methyl binding protein in the development of oocytes were reviewed.

关 键 词：N6-甲基腺苷 卵母细胞发生 甲基转移酶 去甲基酶 甲基结合蛋白 

分 类 号：R711.71[医药卫生—妇产科学]