消痰行气散结散联合中医定向透药治疗气滞痰凝型淋巴结核疗效观察  

Clinical effect of Huatan Xingqi Powder combined with directional penetration for lymphatic tuberculosis of qi stagnation and phlegm coagulation

作　　者：王国卫[1] 李翠乔 段先佳 何萍[1] 梁亚充 WANG Guowei;LI Cuiqiao;DUAN Xianjia;HE Ping;LIANG Yachong(Department of Traditional Chinese Medicine,Hebei Chest Hospital,Shijiazhuang,Hebei 050041;不详)

机构地区：[1]河北省胸科医院中医科,河北石家庄050041 [2]河北省胸科医院结核内科,河北石家庄050041

出　　处：《河北中医》2021年第6期917-921,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2018年度中医药类科研计划课题(编号:2018088)。

摘　　要：目的观察消痰行气散结散联合中医定向透药治疗气滞痰凝型淋巴结核的临床疗效。方法将120例气滞痰凝型淋巴结核患者按照随机数字表法分为2组。对照组60例(后脱落4例)采用基础抗结核方案,治疗组60例(后脱落2例)在对照组治疗基础上予消痰行气散结散联合中医定向透药治疗。2组均1个月为1个疗程,共治疗2个疗程。比较2组治疗前后T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及治疗后中医证候疼痛、低热、乏力缓解率,并统计疗效、复发率及不良反应发生率。结果治疗组总有效率100%(58/58),对照组总有效率91.1%(51/56),治疗组疗效优于对照组(P<0.05)。治疗后治疗组疼痛、低热、乏力缓解率均高于对照组(P<0.05)。治疗后2组CD3+、CD4+、CD4+/CD8+水平均较本组治疗前升高(P<0.05),CD8+水平均降低(P<0.05),且治疗后治疗组CD3+、CD4+、CD4+/CD8+水平均高于对照组(P<0.05),CD8+水平低于对照组(P<0.05)。治疗组复发率低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论消痰行气散结散联合中医定向透药治疗配合基础抗结核方案治疗气滞痰凝型淋巴结核较单纯基础抗结核方案可提高有效率,改善中医证候及T淋巴细胞亚群水平,降低复发率,且未增加不良反应发生率。Objective To observe the Clinical effect Huatan Xingqi Powder combined with directional penetration of traditional Chinese medicine(TCM)for lymphatic tuberculosis(LT)of qi stagnation and phlegm coagulation.Methods Totally 120 patients with LT(qi stagnation and phlegm coagulation)were randomly divided into treatment group(n=60,4 cases of posterior shedding)and control group(n=60,2 cases of posterior shedding).Patients in control group were treated with conventional anti-tuberculosis drug,and patients in treatment group with Huatan Xingqi Powder combined with directional penetration of TCM on the basis of control group,additionally.Treated for 2 months,aiming to compare immune level(CD3+,CD4+,CD8+,CD4+/CD8+),and TCM syndrome;curative effect,recurrence rate and incidence of adverse reactions were counted.Results The total effective rates in treatment group were better than those in control group[100%(58/58)vs 91.1%(51/56),(P<0.05),respectively].TCM syndrome(pain,low-grade fever,fatigue)in treatment group was higher than that in control group;compared with before treatment,CD3+,CD4+,CD4+/CD8+in groups were higher after treatment(P<0.05),which in treatment group were significantly increased(P<0.05);while CD8+in groups was lower(P<0.05),which in treatment group was significantly decreased(P<0.05);the recurrence rate was lower in treatment group than in control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion For patients with LT(qi stagnation and phlegm coagulation),the therapy of Huatan Xingqi Powder combined with directional penetration of TCM has higher efficiency compared with conventional anti-tuberculosis treatment,which can improve TCM syndromes and t-cell subgroup functions,reduce recurrence rate and incidence of adverse reactions.

关 键 词：结核 淋巴结 中药疗法 免疫 

分 类 号：R522.053.1[医药卫生—内科学]