多囊卵巢综合征与宫颈上皮内病变发病风险的相关性研究  

Correlation cohort study of polycystic ovary syndrome and the risk of cervical intraepithelial lesions

作　　者：周雪勤 梁海莹 胡明淼 黄梅香 黄霄燕 唐冬梅 ZHOU Xueqin;LIANG Haiying;HU Mingmiao;HUANG Meixiang;HUANG Xiaoyan;TANG Dongmei(Department of Gynaecology,Wuming Hospital Affiliated to Guangxi Medical University,Wuming 530199,Guangxi,China)

机构地区：[1]广西医科大学附属武鸣医院妇科,广西武鸣530199

出　　处：《中国性科学》2021年第9期52-55,共4页Chinese Journal of Human Sexuality

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200598)。

摘　　要：目的探讨多囊卵巢综合征(PCOS)与宫颈上皮内病变发病风险的关系。方法采用前瞻性队列研究,选取2016年2月至2018年2月广西医科大学附属武鸣医院妇科诊治的656例患者作为研究对象,根据是否诊断为PCOS分为PCOS组(n=152)和非PCOS组(n=504)。对两组进行随访,比较宫颈上皮内病变的发生率,并采用单因素和多因素Cox回归模型分析PCOS与宫颈上皮内病变发病风险的关系。结果平均随访(2.6±0.6)年,PCOS组失访2例,宫颈上皮内病变率为48%(72/150)。非PCOS组失访10例,宫颈上皮内病变率为17.81%(88/494)。PCOS组宫颈上皮内病变率显著高于非PCOS组(P<0.05)。Cox比例风险回归模型1:PCOS组宫颈上皮内病变发病风险是非PCOS组的2.176倍[95%CI(1.990~4.068)];模型2:在模型1的基础上校正了年龄、体重指数(BMI)、高血压、高脂血症,结果显示,PCOS组的宫颈上皮内病变发病风险是非PCOS组的1.820倍[95%CI(1.405~3.550)];模型3:在模型2的基础上进一步校正了糖尿病、吸烟、饮酒、民族、宫颈上皮病变家族史、孕产史、初次性行为年龄、性生活频率、性伴侣数量、避孕方式、人乳头瘤病毒(HPV)阳性率等,结果显示,PCOS组的宫颈上皮内病变发病风险是非PCOS组的1.632倍[95%CI(1.387~3.002)]。结论多囊卵巢综合征会增加宫颈上皮内病变的发病风险,可根据实际情况积极采取措施,控制PCOS的进一步发展。Objective To explore the relationship between polycystic ovarian syndrome(PCOS)and cervical intraepithelial lesions.Methods A prospective cohort study was adopted.The 656 women who visited Department of Gynaecology of Wuming Hospital Affiliated to Guangxi Medical University from February 2016 to February 2018 were divided into PCOS group(n=152)and non-PCOS group(n=504).All subjects were followed up to compare the incidence of cervical intraepithelial lesions between the two groups,and univariate and multivariate Cox regression models were used to analyze the relationship between PCOS and cervical intraepithelial lesions.Results The average follow-up period was(2.6±0.6)years.PCOS group lost 2 cases,the rate of cervical intraepithelial lesions was 48%(72/150).Non-PCOS group lost 10 cases,and the rate of cervical intraepithelial lesions was 17.81%(88/494).The incidence of cervical intraepithelial lesions in PCOS group was significantly higher than that in non-PCOS group(P<0.05).Cox proportional risk regression model 1:the risk of cervical intraepithelial lesions in PCOS group was 2.176 times higher than that in non-PCOS group[95%CI(1.990-4.068)].Model 2:Age,BMI,hypertension and hyperlipidemia were adjusted on the basis of model 1,and the results showed that the risk of cervical intraepithelial lesions in the PCOS group was 1.820 times higher than that in the non-PCOS group[95%CI(1.405-3.550)].Model 3:On the basis of model 2,diabetes,smoking,alcohol consumption,ethnicity,family history of cervical epithelial disease,pregnancy history,age of first sexual intercourse,frequency of sexual intercourse,number of sexual partners,contraceptive method,HPV positive rate,etc.,were further adjusted.The results showed that,the risk of cervical intraepithelial lesions in the PCOS group was 1.632 times higher than that in the non-PCOS group[95%CI(1.387-3.002)].Conclusions Polycystic ovary syndrome will increase the risk of cervical intraepithelial lesions.Measures can be taken to control the further development of PCOS according t

关 键 词：多囊卵巢综合征 宫颈上皮内病变 风险 前瞻性队列研究 

分 类 号：R711[医药卫生—妇产科学]