卡介苗多糖核酸肌内注射联合液氮冷冻疗法对女性外阴尖锐湿疣的疗效及其对Patched-1、Gli-1、Smo蛋白的影响  

The curative effect of intramuscular injection of BCG polysaccharide nucleic acid combined with cryotherapy on female condyloma acuminatum and the effect of Patched-1,Gli-1 and Smo protein

作　　者：赵峰[1] 李红娟 蔺秀香 ZHAO Feng;LI Hongjuan;LIN Xiuxiang(Department of Dermatology,Qingdao Eighth People's Hospital,Qingdao 266100,Shandong,China)

机构地区：[1]青岛市第八人民医院皮肤科,山东青岛266100

出　　处：《中国性科学》2021年第9期142-145,共4页Chinese Journal of Human Sexuality

摘　　要：目的研究卡介苗多糖核酸联合液氮冷冻疗法对女性尖锐湿疣的治疗效果,以及对患者Patched-1、Gli-1和Smo蛋白水平的影响。方法选择2016年3月至2019年10月青岛市第八人民医院诊治的120例女性外阴尖锐湿疣患者作为研究对象。按照随机数字法将患者分为观察组和对照组,每组60例。对照组采用液氮冷冻疗法,观察组在对照组的基础上加用卡介苗多糖核酸肌内注射。对两组治疗前后的炎症因子[白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、超敏C反应蛋白(hs-CRP)]水平进行检测;对两组治疗前后的皮肤受损面积、治疗效果以及6个月的复发率和不良反应进行检查记录;对两组皮肤组织液中Patched-1、Gli-1和Smo蛋白水平进行检测。结果观察组的治疗总有效率为85.00%,明显高于对照组的65.00%,差异具有统计学意义(P<0.05);治疗后,观察组的患处面积小于对照组,观察组的IL-6、IL-18和hs-CRP水平低于对照组,观察组的Patched-1、Gli-1和Smo蛋白水平低于对照组,差异具有统计学意义(P<0.05)。结论应用液氮冷冻疗法联合卡介苗多糖核酸肌内注射治疗女性尖锐湿疣的效果显著,能够有效降低患者Patched-1、Gli-1和Smo蛋白水平。Objective To study the therapeutic effect of combined therapy of BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy on female condyloma acuminata,and the effect on the protein levels of Patched-1,Gli-1 and Smo in patients.Methods 120 female patients with condyloma acuminatum treated in Qingdao Eighth People's Hospital from March 2016 to October 2019 were selected as the research object.According to the random number method,patients were divided into observation group and control group,60 cases in each group.The control group was treated with liquid nitrogen cryotherapy,and the observation group was treated with BCG polysaccharide nucleic acid intramuscular injection on the basis of the control group.The levels of inflammatory cytokines[interleukin-6(IL-6),interleukin-18(IL-18)and hypersensitive C-reactive protein(hs-CRP)]were detected before and after treatment in both groups.The skin damaged area,treatment effect,recurrence rate and adverse reactions of 6 months before and after treatment were recorded.The protein levels of Patched-1,Gli-1 and Smo in skin tissue fluid of the two groups were detected.Results The total effective rate of observation group was 85.00%,which was significantly higher than that of control group(65.00%),and the difference was statistically significant(P<0.05).After treatment,the affected area of the observation group was smaller than the control group,the levels of IL-6,IL-18 and hs-CRP in the observation group were lower than the control group,and the protein levels of Gli-1,Smo in the observation group were lower than the control group(P<0.05).Conclusions Liquid nitrogen cryotherapy combined with BCG intramuscular injection can significantly treat female condyloma acuminata,and can effectively reduce the protein levels of Patched-1,Gli-1 and Smo.

关 键 词：液氮冷冻 卡介苗多糖核酸 尖锐湿疣 Patched-1 Gli-1 SMO 

分 类 号：R759[医药卫生—皮肤病学与性病学]