光对生物钟和糖脂代谢的影响  

Effects of Light on Biological Clocks and Metabolism

作　　者：范晓静 邱海霞[2] 王颖[2] 谭一舟 郭向欢 顾瑛[2,3] FAN Xiao-jing;QIU Hai-xia;WANG Ying;TAN Yi-zhou;GUO Xiang-huan;GU Ying(Graduate School of the PLA General Hospital,Beijing 100853,China;Department of laser medicne,the First Medical Center of the PLA General Hospital;Chinese Academy of Medical Sciences Research Unit,Medical School of Chinese PLA)

机构地区：[1]解放军医学院,北京市100853 [2]解放军总医院第一医学中心激光医学科 [3]中国医学科学院

出　　处：《中国激光医学杂志》2021年第4期216-222,共7页Chinese Journal of Laser Medicine & Surgery

基　　金：国家重点研发计划项目(2017YFB0403800);中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-061)。

摘　　要：昼夜节律系统由生物钟驱动,通过调节新陈代谢相关的关键酶、激素等,调控机体内部代谢过程,从而使生物体预测并适应外界昼夜变化的环境。光是调节昼夜节律与外界环境同步的最重要的信号,异常光照引起的昼夜节律紊乱可增加代谢性疾病的患病风险。本文阐述了光调节生物钟的分子机制和同步昼夜生物节律的特点,总结了异常光照与糖脂代谢紊乱相关疾病联系的最新研究进展。Circadian timekeeping systems,controlled by biological clocks,allow appropriate organisms’internal metabolism by temporal regulation of metabolic key enzymes and hormones to anticipate and respond to recurrent daily changes in the environment.Environmental light is a key stimulus that synchronizes the internal circadian system with external time cues.Circadian disruption by light has been reported to increase susceptibility to metabolic diseases.In this review,the molecular mechanism of light regulating circadian clocks and effect of light resetting circadian rhythm is introduced.Furthermore,the evidence for the interactions between aberrant light and metabolism disorder is reviewed.All these efforts are made for a better understanding of the mechanism through which light may exert its effects on metabolism by disrupting circadian rhythms as it will provide new prevention strategies for metabolism disorder.

关 键 词：光 昼夜节律 糖代谢 脂代谢 

分 类 号：R312[医药卫生—基础医学] R852.6