HIV Compartmentalization in Male Genital Tract:Relevance for Viral Eradication  

作　　者：Xiaorong Peng Stéphane Isnard John Lin Brandon Fombuena Lena Royston Jean-Pierre Routy 

机构地区：[1]Infectious Diseases and Immunity in Global Health Program,Research Institute,McGill University Health Centre,Montréal,QC,Canada [2]Chronic Viral Illness Service,McGill University Health Centre,Montréal,QC,Canada [3]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310006,China [4]CIHR Canadian HIV Trials Network,Vancouver,BC,Canada [5]Division of Hematology,McGill University Health Centre,Montréal,QC,Canada

出　　处：《Infectious Diseases & Immunity》2021年第2期86-92,共7页感染性疾病与免疫（英文）

基　　金：This work was funded by the China Scholarship Council(No.201906325018);the Canadian Institutes of Health Research(CIHR;grants MOP 103230 and PTJ 166049);the Vaccines&Immunotherapy Core of the CIHR Canadian HIV Trials Network(CTN,grant CTN 257);the CIHR-funded Canadian HIV Cure Enterprise(CanCURE)Team Grant HB2-164064;This work was also supported by the Fonds de la Recherche Quebec-Sante(FRQ-S):Reseau SIDA/Maladies infectieuses and Therapie cellulaire.Stephane Isnard is supported by a Fond de Recherche Quebec Santefellowship and a CIHR/CTN Postdoctoral Fellowship Award.Jean-Pierre Routy is the holder of the Louis Lowenstein Chair in Hematology and Oncology,McGill University and William Turner award holder from the McGill University Health Centre.

摘　　要：Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical compartments.Characterizing HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral reservoir.HIV compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)organs.The precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these tissues.Based on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular microenvironment.We reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected people.Characterizing distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.

关 键 词：HIV COMPARTMENTALIZATION Male genital tract Reservoir TESTES 

分 类 号：R512.91[医药卫生—内科学]