从“五脏相关”理论探讨肝纤维化病机变化特点  

Discussion on characteristics of pathological changes of hepatic fibrosis based on the theory of‘correlation between five zang viscera’

作　　者：刘定[1] 曹洪欣[2] 潘富珍 LIU Ding;CAO Hong-xin;PAN Fu-zhen(Heilongjiang University of Chinese Medicine,Harbin 150040,China;China Association of Chinese Medicine,Beijing 100029,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]中华中医药学会,北京100029

出　　处：《中华中医药杂志》2021年第8期4512-4514,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：黑龙江省自然科学基金项目(No.LH2019H109)。

摘　　要：从中医“五脏相关”理论,结合临床和实验研究探讨肝纤维化的病机变化特点,提出“肝受气于心,肝血瘀滞,肝病传脾,脾虚湿阻,肝不藏血,肝肾亏损”为肝纤维化病机的基本演变规律,而肝血瘀滞是肝纤维化疾病的病理基础。肝纤维化形成过程中存在的多种促纤维化和抗纤维化失衡的微环境特点可能是肝脾肾脏腑功能失调的微观体现。在“以平为期”理论指导下,结合肝纤维化的临床进展特点提出“肝脾肾同治”的治疗方法,为中医治疗肝纤维化提供新的思路。It is considered that the features of‘liver reception of qi from heart,liver blood stasis,liver disease spreading into spleen,spleen deficiency with resistance of dampness,liver failing to store blood and deficiency and detriment of liver and kidney’,which are based on the theory of‘correlation between five zang viscera’of Chinese medicine and research of clinical and experimental,is the basic evolution law of the pathogenesis of hepatic fibrosis,while liver blood stasis is the pathological basis of hepatic fibrosis.The microenvironment characteristics of promoting fibrosis and anti-fibrosis imbalance in the process of hepatic fibrosis may be the microscopic embodiment of the dysfunction of liver,spleen and kidney.The therapy of‘synergistic treatment of liver,spleen and kidney’which is based on the theory of‘aim for harmony’and clinical manifestation of hepatic fibrosis provide a new way for the treatment of hepatic fibrosis by Chinese medicine.

关 键 词：五脏相关 肝纤维化 中医病机 肝血瘀滞 病机演变 肝脾肾同治 

分 类 号：R259[医药卫生—中西医结合]