基于转移前微环境探讨结直肠癌核心病机生物学基础  

Discussion on the biological basis of the core pathogenesis of colorectal cancer based on pre-metastasis niches

作　　者：张钦畅 程海波[1] ZHANG Qin-chang;CHENG Hai-bo(The First Clinical College of Nanjing University of Chinese Medicine,Jiangsu Collaborative Innovation Center of TCM Prevention and Treatment of Tumor,Nanjing 210023,China)

机构地区：[1]南京中医药大学第一临床医学院,江苏省中医药防治肿瘤协同创新中心,南京210023

出　　处：《中华中医药杂志》2021年第8期4519-4522,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金重点项目(No.81930117);国家重点研发计划项目(No.2017YFC1700602);江苏高校优势学科建设工程资助项目(PAPD)。

摘　　要：肿瘤转移是导致恶性肿瘤难治和病死的主要原因,转移前微环境(PMNs)的形成为肿瘤转移营造了适宜的环境,因此识别和靶向PMNs中的关键因子可有效抑制肿瘤转移。癌毒病机理论认为“湿热瘀毒,脾气亏虚”是结直肠癌发生转移的核心病机。通过探讨结直肠癌的核心病机与PMNs的相关性,阐明PMNs可能是结直肠癌核心病机的生物学基础,进一步揭示结直肠癌核心病机的科学内涵,为临床运用癌毒病机理论辨治肠癌转移提供科学依据。Tumor metastasis is the main cause of refractory and death of malignant tumor.The formation of premetastasis niches(PMNs)creates a suitable environment for tumor metastasis,therefore,the identification and targeting of key factors in PMNs can effectively inhibit tumor metastasis.The pathogenesis theory of cancer toxin holds that‘damp-heat and blood stasis,spleen-qi deficiency’is the core pathogenesis of colorectal cancer metastasis.By discussing the correlation between the core pathogenesis of colorectal cancer and the PMNs,this paper clarifies that the PMNs may be the biological basis of the core pathogenesis of colorectal cancer,and further reveals the scientific connotation of the core pathogenesis of colorectal cancer.To provide scientific basis for clinical application of cancer toxin pathogenesis theory in the diagnosis and treatment of colorectal cancer metastasis.

关 键 词：癌毒病机理论 结直肠癌 转移前微环境 核心病机 生物学基础 肿瘤转移 

分 类 号：R273[医药卫生—中西医结合]