糖肽高分子材料及生物医学应用  

Glycopeptide-Based Polymers and Their Biomedical Applications

作　　者：张婧楷 刘潇璇 李莉莉[2] ZHANG Jingkai;LIU Xiaoxuan;LI Lili(State Key Laboratory of Natural Medicines,Center of Advanced Pharmaceuticals and Biomaterials,China Pharmaceutical University,Nanjing 210009,China;CAS Center for Excellence in Nanoscience,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China)

机构地区：[1]中国药科大学,天然药物活性组分与药效国家重点实验室,药物科学研究院高端药物制剂与材料研究中心,南京210009 [2]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,中国科学院纳米科学卓越创新中心,北京100190

出　　处：《功能高分子学报》2021年第5期401-417,共17页Journal of Functional Polymers

基　　金：国家自然科学基金(51873045);国家重点研发计划项目(2018YFE0205400)。

摘　　要：糖肽高分子材料是一类由多肽和糖类化合物构成的高分子材料。糖肽高分子材料具有与天然糖肽/糖蛋白类似的化学组成,能够在一定程度上模拟天然糖肽/糖蛋白的结构和功能。本文总结了糖肽高分子材料的合成方法、材料设计及其在生物医学领域的应用,重点综述了糖肽高分子材料在糖肽树形分子、自组装糖肽和糖肽聚合物方面的材料设计,以及糖肽高分子材料在抗菌、抗肿瘤疫苗、仿生支架、组织及软骨修复方面的应用。最后,对糖肽高分子材料的发展与前景进行了展望。Glycopeptide-based polymers are a kind of biodegradable polymers composed of polypeptides and carbohydrates.Owing to their chemical similarity to natural glycopeptides and glycoproteins,they can mimic the structure and function of natural products.There are two main types of glycosides:N-glycosides and O-glycosides.Glycosides are coupled with amino acids in advance to form glycosylated amino acid building blocks,and then participate in the synthesis of glycopeptides together with amino acids in solid phase synthesis.Native chemical ligation is often used to synthesize longer glycopeptide that cannot be obtained by solid phase synthesis.Glycopeptides are designed to reflect multivalence,so the most common types include branched glycopeptides,self-assembled glycopeptides and polymer glycopeptides.Branched glycopeptides mainly include glycopeptide dendrimers.Self-assembled glycopeptides mainly consist of modifying various glycosyl groups on self-assembled polypeptides.Based on these self-assembled glycopeptides,glycopeptide materials can self-assemble into various nanostructures,such as micelles,vesicles,fibers and nanorods.As a kind of structural mimic of natural glycoproteins,synthetic glycopeptides can play a variety of biomedical roles. Synthetic glycopeptides are capable of binding to lectin or adhesive of bacteria or targeting intracellular bacteria of macrophages. Due to the overexpression of carbohydrate-binding proteins on tumor cells surfaces, glycopeptides have been widely investigated as an anti-tumor vaccine. In addition, glycopeptide-based hydrogels can be used as a biomimetic scaffold for mammalian cells growth due to their high-water content and similar structure, shape and composition to the extracellular matrix (ECM) in tissues. Glycopeptides can also simulate natural glycosaminoglycans to play a role in tissue and cartilage repair. We summarize the synthesis method, material design and biomedicine application of glycopeptides, focusing on the material design of glycopeptides in branched glycopepti

关 键 词：糖肽高分子材料 自组装 树形分子 抗菌 

分 类 号：O636[理学—高分子化学]