经支气管镜肺泡灌洗对难治性肺炎支原体肺炎疗效及血清白细胞介素-6、肿瘤坏死因子-α水平影响  

Effect of bronchoalveolar lavage on serum interleukin-6 and tumor necrosis factor-α in patients with refractory Mycoplasma pneumonia

作　　者：朱红国 汪群红 管敏昌 沈林云 杭金国[4] 王丽珍 ZHU Hong-guo;WANG Qun-hong;GUAN Min-chang;SHEN Un-yun;HANG Jin-guo;WANG D-zhen(Clinical Laboratory,Taizhou Enze Hospital,Taizhou,Zhejiang 318050,China;不详)

机构地区：[1]台州恩泽医院检验科,浙江台州318050 [2]台州恩泽医院中药房,浙江台州318050 [3]台州恩泽医院儿科,浙江台州318050 [4]台州医院路桥院区儿科,浙江台州318050

出　　处：《中国卫生检验杂志》2021年第18期2234-2236,2241,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生项目(2015KYB446)。

摘　　要：目的 探讨经支气管镜肺泡灌洗对难治性肺炎支原体肺炎疗效及血清IL-6、TNF-α水平影响。方法 选择2017年4月-2019年10月本院难治性肺炎支原体肺炎患儿100例,将拒绝支气管肺泡灌洗治疗的50例为对照组,将接受支气管肺泡灌洗的50例为观察组,比较2组临床疗效及入院时、入院第1周、入院第2周血清IL-6、TNF-α水平。结果 临床疗效观察组显著优于对照组(χ2=17. 6,P <0. 01)。血清IL-6水平;入院第1周观察组显著低于对照组(t=4. 40,P <0. 01);入院第2周观察组显著低于对照组(t=6. 12,P <0. 01);血清TNF-α水平;入院第1周观察组显著低于对照组(t=2. 82,P <0. 01);入院第2周观察组低于对照组更明显,上述差异均有统计学意义(t=3. 30,P <0. 01)。结论 支气管肺泡灌洗可显著提高难治性肺炎支原体肺炎疗效,可降低难治性肺炎支原体肺炎患儿血清IL-6和TNF-α水平。Objective To study the effect of bronchoalveolar lavage on serum interleukin-6 and tumor necrosis factor-α in patients with refractory Mycoplasma pneumonia.Methods A total of 100 children with refractory Mycoplasma pneumonia in our hospital were selected from April 2017 to October 2019.50 cases who refused bronchoalveolar lavage were selected as the control group and 50 cases who received bronchoalveolar lavage were selected as observation group.Then the clinical effect and levels of interleukin-6 and tumor necrosis factor-α in serum at admission,the first week and the second week were compared between the two groups.Results The clinical efficacy in the observation group was significantly better than that in the control group(χ^(2)=17.6,P<0.01).The level of IL-6 in the observation group was significantly lower than that in the control group at the first week of admission(t=4.40,P<0.01);while it was significantly lower in the observation group than that in the control group at the second week of admission(t=6.12,P<0.01);the level of tumor necrosis factor-α in the observation group was significantly lower than that in the control group at the first week of admission(t=2.82,P<0.01);while that in the observation group was significantly much lower than that in the control group at the second week of admission,with the above differences statistically significant(t=3.30,P<0.01).Conclusion Bronchoalveolar lavage can significantly improve the curative effect of mycoplasma pneumoniae pneumonia(RMPP)and reduce the serum levels of interleukin-6 and tumor necrosis factor-α in children with RMPP.

关 键 词：支气管泡灌洗 难治性肺炎支原体肺炎 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R446[医药卫生—诊断学]