应用能谱CT分析退行性腰椎皮质羟基磷灰石和钙含量  

Analysis of the Content of Hydroxyapatite and Calcium in Degenerative Lumbar Cortex by Spectrum CT

作　　者：马欢 罗嗣频 傅菲[2] 邓欣[2] 万业达[2] MA Huan;LUO Sipin;FU Fei;DENG Xin;WAN Yeda(Graduate School,Tianjin Medical University,Tianjin 300202,China;Department of Radiology,Tianjin Hospital,Tianjin 300202,China)

机构地区：[1]天津医科大学研究生院,天津300202 [2]天津市天津医院放射一科,天津300202

出　　处：《中国医疗设备》2021年第10期96-99,共4页China Medical Devices

摘　　要：目的利用能谱CT物质分离技术分析腰椎退行性骨性关节病椎体皮质的羟基磷灰石(Hydroxyapatite,HAP)含量以及钙(Calcium,Ca)含量。方法收集2020年9月至2021年1月78例行腰椎CT平扫的患者,采用CT能谱扫描方式重建出HAP(water)基物质图和Ca(water)基物质图,在正中矢状面上分别测得椎体前缘、椎体上缘、椎体下缘和椎体后缘皮质的平均HAP密度值和Ca密度值。比较椎体各边缘、不同年龄段(50~59岁组1<60、60~69岁组、70~79岁组)和不同性别间测量值的差异。采用单因素方差分析比较椎体四个边缘及在不同年龄段之间HAP和Ca密度值的差异;使用独立样本t检验比较不同性别中椎体四个边缘的HAP和Ca密度值的差异。结果椎体前缘、上缘、下缘以及后缘皮质的HAP密度值和Ca密度值差异有统计学意义(P值均<0.01),两种物质的密度值均表现为上缘和下缘皮质差异无统计学意义、前缘密度值高于上缘和下缘、后缘密度值低于上缘和下缘。不同年龄比较中,仅在组2和组3的上缘HAP含量和Ca含量差异有统计学意义(P=0.009,P=0.019)。不同性别比较时,前缘和下缘的HAP密度值(P<0.01,P=0.026)和Ca密度值(P<0.01,P=0.018)差异有统计学意义。结论能谱CT物质分离技术可以定量分析椎体皮质的HAP和Ca含量,有助于判定退行性病变程度、进一步阐明腰椎退行性变的发病机制。Objective To analyze the content of hydroxyapatite(HAP)and calcium(Ca)in the vertebral cortex of lumbar degenerative osteoarthropathy by spectral CT material separation technique.Methods A total of 78 patients(44 males and 34 females)with an average age of(64.66±6.43)who underwent plain CT scan of the lumbar spine from September 2020 to January 2021 were collected.The HAP(water)and CA(water)-based material images were reconstructed by the CT spectral scanning mode,and the average HAP density values and Ca density values of the anterior,upper,lower,and posterior vertebral cortices of the vertebral body were measured on the midsagittal plane.The differences of measured values at each edge of vertebral body,different age groups(50≤group 1<60,60≤group 2<70 and 70≤group 3<80)and different genders were compared.One-way analysis of variance was used to compare the differences of HAP and Ca density values between the four edges of vertebral body and different age groups;independent sample t-test was used to compare the differences of HAP and Ca density values at four edges of vertebral body in different genders.Results There were significant differences in HAP density and Ca density between the upper,lower,anterior and posterior margins of the vertebral body cortex(P all<0.01).The density values of the two substances both showed that there was no significant difference between the upper and lower edges cortex.The density values of the anterior edge were higher than that of the upper and lower margins,and the density values of the posterior edge were lower than that of the upper and lower edges.In the comparison of different ages,there was only significant difference in the content of HAP and Ca in the upper edge of group 2 and group 3(P=0.009,P=0.019).The HAP density values of the upper edge and the lower edge(P<0.01,P=0.026)and Ca density(P<0.01,P=0.018)were statistically significant in different genders.Conclusion Spectral CT material separation technology can quantitatively analyze the HAP and Ca content in the

关 键 词：能谱CT 物质分离 椎体皮质 羟基磷灰石 钙 

分 类 号：R312[医药卫生—基础医学]