雌激素代谢相关的绝经后骨质疏松机制及中医药研究进展  

Mechanism of PMOP Related to Estrogen Metabolism and Its Treatment Advances with TCM

作　　者：王嘉蕙 徐文婷[1] 汤梦雨 钱海晴 王志荣 王利红[1] WANG Jiahui;XU Wenting;TANG Mengyu;QIAN Haiqing;WANG Zhirong;WANG Lihong(Department of Reproductive of Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, China)

机构地区：[1]南京中医药大学张家港附属医院生殖科,江苏张家港215600

出　　处：《中医药学报》2021年第10期98-104,共7页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(82074473);江苏省自然科学基金项目(BK20191201);姑苏卫生人才培养项目(GSWS2019074);苏州市科技发展计划(SYSD2017008)。

摘　　要：绝经后骨质疏松是妇女绝经后的常见疾病之一,以全身骨痛及易发生骨折为临床特点,严重影响中老年妇女的生活质量及远期寿命。目前以雌激素下降为主的内分泌改变常被认为是引起绝经后骨质疏松的主要原因。本文围绕绝经后妇女雌激素水平下降的基础特点,从骨代谢、肠道菌群和氧化应激等方面探讨绝经后骨质疏松的病理机制,并探讨作中医药在干预本病中的具体机制,总结中医药治疗绝经后骨质疏松的优势,为临床治疗提供新思路。Postmenopausal osteoporosis(PMOP)is one of the most common postmenopausal diseases in women.The clinical characteristics of PMOP include systemic bone pain and susceptibility to fracture,which seriously affect the quality of life and long-term life of middle-aged and elderly women.At present,the decrease of estrogen is often considered as the main cause of PMOP.This study explored the mechanism of PMOP in terms of bone metabolism,intestinal flora and oxidative stress,based on the decline of estrogen level in the women with PMOP.It discussed the specific mechanism of TCM in the intervention of PMOP,summarized the advantages of TCM in the treatment of the disease,so as to provide new ideas for its clinical treatment.

关 键 词：雌激素 绝经后骨质疏松 机制 中医药 

分 类 号：R258.9[医药卫生—中医内科学]