美沙西汀-甲氧基-^(13)C及其类似物的合成  

Synthesis of Methacetin-Methoxy-^(13)C and its Analogue

作　　者：陈凯 代德胜 王春玲 魏翠雯 卿晶 沈桂富 CHEN Kai;DAI Desheng;WANG Chunling;WEI Cuiwen;QING Jing;SHEN Guifu(Shenzhen Zhonghe Headway Bio-Sci&Tech Co.,Ltd.,Shenzhen 518057,China)

机构地区：[1]深圳市中核海得威生物科技有限公司,广东深圳518057

出　　处：《同位素》2021年第5期480-486,I0004,共8页Journal of Isotopes

摘　　要：美沙西汀-甲氧基-^(13)C是一种最具潜力的标记底物,用于呼气检测肝功能。本研究以甲醇-^(13)C为标记原料,通过Mitsunobu反应、官能团修饰高效合成了美沙西汀-甲氧基-^(13)C,合成收率为63%,产品纯度>99%。同时应用该方法以甲醇-^(13)C为标记原料合成了对甲氧基苯甲酸-甲氧基-^(13)C,合成收率为67%,产品纯度>99%。建立的合成美沙西汀-甲氧基-^(13)C的新方法可为呼气检测肝功能研究的开展提供参考。In the current research on^(13)C-labeled compounds breath test of liver function,methacetin-methoxy-^(13)C is the most potential substrate.To study a new method for synthesis methacetin-methoxy-^(13)C,methanol-^(13)C was used as the labeled material,methacetin-methoxy-^(13)C was synthesized efficiently through Mitsunobu reaction and functional group modification.The synthesis yield was 63%and the chemical purity was above 99%.At the same time,this method was used to synthesize 4-methoxybenzoic acid-methoxy-^(13)C with methanol-^(13)C as the labeled material.The synthesis yield was 67%and the chemical purity was above 99%.The new scheme for the synthesis of methacetin-methoxy-^(13)C with Mitsunobu reaction as the key reaction could provide a basis for the study of liver function by breath test.

关 键 词：甲醇-^(13)C 美沙西汀-甲氧基-^(13)C 对甲氧基苯甲酸-甲氧基-^(13)C MITSUNOBU反应 

分 类 号：O628.21[理学—有机化学]