Tau蛋白显像剂的研究进展  

Discovery and Development of Tau Imaging Agent

作　　者：于倩[1] 李钰莹 彭程[1] YU Qian;LI Yuying;PENG Cheng(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;College of Chemistry,Beijing Normal University,Beijing 100875,China)

机构地区：[1]首都医科大学宣武医院放射学与核医学科,北京100053 [2]放射性药物教育部重点实验室北京师范大学化学学院,北京100875

出　　处：《同位素》2021年第5期487-497,I0004,共12页Journal of Isotopes

摘　　要：由高度磷酸化的Tau蛋白聚集形成的神经纤维缠结(neurofibrillary tangles,NFTs)被认为是神经退行性疾病的一个重要病理学特征,包括阿尔茨海默病(Alzheimer’s disease,AD)和其他额颞叶痴呆。近年来,许多化学分子探针作为核医学显像剂被陆续报道,以期望对这些神经退行性疾病尤其是AD实现早期的无创诊断。本文综述了目前生物性质较为优良的Tau蛋白SPECT显像剂和已进入临床评估阶段的Tau蛋白PET显像剂的研究进展。Neurofibrillary tangles(NFTs)are regard as a crucial pathological hallmark of various neurodegenerative disorders,including Alzheimer’s disease(AD)and some frontotemporal dementias.Recently,a diversity of chemical molecules has been reported as imaging agents.These probes utilizes nuclear medicine imaging to achieve early noninvasive diagnosis of neurodegenerative diseases,especially AD.In this review,we focus on SPECT probes and several Tau-PET tracers in clinical trials.

关 键 词：阿尔茨海默病诊断 Tau显像剂 SPECT显像 PET显像 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.9[医药卫生—影像医学与核医学]