CYP2D亚家族基因及其进化机制研究进展  

Advanced in CYP2D Subfamily Genes and Evolutionary Mechanisms

作　　者：梁秋芳 董小燕 冯平 LIANG Qiufang;DONG Xiaoyan;FENG Ping(Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University),Ministryof Education,Guilin Guangxi 541006,China;College of Life Sciences,Guangxi Normal University,Guilin Guangxi 541006,China)

机构地区：[1]珍稀濒危动植物生态与环境保护教育部重点实验室(广西师范大学),广西桂林541006 [2]广西师范大学生命科学学院,广西桂林541006

出　　处：《广西师范大学学报（自然科学版）》2021年第5期58-63,共6页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金(32060111);广西自然科学基金(2018GXNSFBA281010);广西师范大学珍稀濒危动植物生态与环境保护教育部重点实验室基金(GKN.19-A-01-07)。

摘　　要：CYP2D酶在药物代谢及有毒物质的解毒过程中起重要作用,而认识和了解CYP2D亚家族基因的适应性进化有助于理解CYP2D酶对有毒物质的作用机制。研究表明,CYP2D亚家族基因在进化过程中具有谱系特异性扩张现象。此外,基因复制、基因转换以及选择压力对基因的进化具有一定的影响,但对不同谱系产生的影响程度不同。本文从CYP2D亚家族基因的结构、功能及其进化机制等方面进行综述,以期为理解CYP2D亚家族基因的适应性进化提供理论依据。CYP2D enzyme plays an important role in drug metabolism and the detoxification of toxic substances.Knowing and understanding the adaptive evolution of CYP2D subfamily genes helps to understand the mechanism of CYP2D enzymes on toxic substances.Research has shown that CYP2D subfamily genes have lineage-specific expansion in the evolutionary process.In addition,gene duplication,gene conversion,and selective pressure had a certain influence on the evolution of genes,but the effect varied with different lineages.In this paper,the structure,function and evolutionary mechanism of CYP2D subfamily genes were reviewed,in order to provide a theoretical basis for understanding the adaptive evolution of CYP2D subfamily genes.

关 键 词：细胞色素P450 CYP2D基因 基因复制 基因转换 选择压力 

分 类 号：Q31[生物学—遗传学]