苯乙炔基硼酸酯与对醌甲基化合物的炔基化反应  

Alkynylation Reaction of Phenyl-ethynyl Borate and p-quinone Methyl Compound

作　　者：蒲凡 何龙[1] PU Fan;HE Long(College of Chemistry and Chemical Engineering,China West Normal University,Sichuan Nanchong 637000,China)

机构地区：[1]西华师范大学化学化工学院,四川南充637000

出　　处：《广州化工》2021年第19期44-45,98,共3页GuangZhou Chemical Industry

基　　金：四川省教育厅资助(18ZA0461)。

摘　　要：碳碳三键的构建在有机化学中得到了广泛研究,炔基硼酸酯对迈克尔受体的加成是有机合成中构建碳碳叁键最重要的反应之一。因此,我们使用苯乙炔硼酸异丙酯和对醌甲基化合物(p-QMs)发生迈克尔加成反应,这一策略可以构造含两个酚羟基的叔碳中心苯乙炔化合物。本文实现了无催化剂条件下,对醌甲基化合物(p-QMs)能够和苯乙炔硼酸酯发生炔基化反应。温和条件下,对反应底物普适性进行了考察,得到了较好的结果。The construction of carbon-carbon triple bonds has been extensively studied in Organic Chemistry.The addition of alkynyl borate to the Michael acceptor is one of the most important reactions of formation carbon-carbon triple bonds in Organic Chemistry.Therefore,phenylacetylene borate and p-quinone methyl compounds(p-QMs)were used to undergo the Michael addition reaction.This strategy can construct a phenylacetylene compound containing two phenolic hydroxyl groups with a tertiary carbon center.The ruthenium methyl compounds(p-QMs)were capable of reacting with phenylacetylene boronate without catalyst under mild conditions,the universality of the reaction substrate was investigated,and good results were obtained.

关 键 词：苯乙炔硼酸酯 对醌甲基化合物 无催化剂 

分 类 号：O625.63[理学—有机化学]