早产儿DEHSI与PVL对脑发育成熟度的影响  

The effect of DEHSI and PVL on brain development maturity in preterm infants

作　　者：班耀丹 徐萌 靳京 马得廷[2] Ban Yaodan;Xu Meng;Jin Jing;Ma Deting(Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271016,China;Taian City Central Hospital,Taian 271000,China)

机构地区：[1]山东第一医科大学(山东省医学科学院),山东泰安271016 [2]泰安市中心医院,山东泰安271000

出　　处：《山东第一医科大学（山东省医学科学院）学报》2021年第9期670-674,共5页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

摘　　要：目的应用总体发育成熟度评分(TMS)评价早产儿中重度脑白质弥漫性过度高信号(DEHSI)和脑室周围白质软化症(PVL)对脑发育成熟度的影响。方法回顾性分析68例新生儿颅脑MR图像,分为三组:正常早产儿组、DEHSI组和PVL组(校正胎龄为37~44周),利用TMS对每个新生儿颅脑MR图像进行评价,比较各组之间的TMS得分。结果正常早产儿组在髓鞘形成、皮质卷曲、TMS总分方面得分与DEHSI早产儿组之间的差异具有统计学意义(P<0.05);在髓鞘形成、皮质卷曲、TMS总分得分中,由高到低依次为正常早产儿组、PVL患儿组、DEHSI早产儿组;任意两组间在生发基质方面和移行细胞带方面得分的差异无统计学意义(P>0.05)。结论脑白质存在DEHSI和PVL可以影响早产儿的大脑发育成熟度,二者对大脑发育成熟度的影响程度不同。DEHSI会延迟大脑的发育成熟度。Objective:To evaluate the effects of diffuse excessive high signal intensity(DEHSI)and periventricular leukomalacia(PVL)on brain development maturity of premature infants by total maturational scores(TMS).Methods:Retrospective analysis was performed on the craniocerebral MR images of 68 neonates,which were divided into three groups:normal preterm infants group,DEHSI group and PVL group(adjusted gestational age:37-44 weeks).The craniocerebral MR images of each newborn were evaluated by the TMS.The TMS scores were compared between the groups.Results:There were statistically significant differences in myelination,cortical infolding and TMS scores between the normal preterm infants and the DEHSI preterm infants(P<0.05);In the scores of myelination,cortical infolding and TMS,the order from high to low was normal preterm infants group,PVL infants group,DEHSI preterm infants group;There were no statistically significant differences in germinal matrix and migrating glial cells scores between any two groups(P>0.05);Conclusion:The presence of DEHSI and PVL in the white matter of preterm infants affects the developmental maturity of the brain,and DEHSI and PVL have different effects on the developmental maturity of the brain.DEHSI does delay the developmental maturity of the brain.

关 键 词：早产儿 脑发育 脑白质弥漫性过度高信号 脑室周围白质软化症 总体发育成熟度评分 

分 类 号：R445.2[医药卫生—影像医学与核医学]