系统性红斑狼疮的肺损害  

Pulmonary damage associated with systemic lupus erythematosus

作　　者：杨吉娟[1] 池淑红[1] YANG Ji-juan;CHI Shu-hong(Department of Rheumatology and Immunology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院风湿免疫科,宁夏银川750004

出　　处：《中国实用内科杂志》2021年第9期749-752,756,共5页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金(81860132)。

摘　　要：系统性红斑狼疮(SLE)的特征是产生致病性自身抗体和免疫复合物,导致多器官受累。肺损害是其常见的并发症,包括胸膜疾病、急性狼疮性肺炎、间质性肺疾病、弥漫性肺泡出血、肺栓塞、肺动脉高压、呼吸道疾病、肺萎缩综合征、肺恶性肿瘤和感染等。临床表现从无症状(如少量胸腔积液)到威胁生命的疾病(如急性狼疮性肺炎或弥漫性肺泡出血)。根据肺部受累类型和严重程度,使用糖皮质激素、免疫抑制剂、血浆置换以及干细胞治疗。治疗过程中需警惕免疫抑制剂本身所致肺损害。Systemic lupus erythematosus(SLE)is an autoimmune rheumatic disease characterized by the production of pathogenic autoantibodies and immune complexes,leading to multiple organ involvement. Lung damage is a common complication,including pleural disease,acute lupus pneumonitis,interstitial lung disease,diffuse alveolar hemorrhage,pulmonary embolism,pulmonary hypertension,airway disease,shrinking lung syndrome,lung cancer and infection,etc.Conditions can range mostly from asymptomatic(such as in mild cases of pleural effusion)to life-threatening disease(such as in acute lupus pneumonitis or diffuse alveolar hemorrhage). According to the type and severity of lung involvement,glucocorticoids,immunosuppressants,plasma exchange,and stem cell therapy are used. In the course of treatment,it is necessary to guard against lung damage caused by immunosuppressive agents.

关 键 词：系统性红斑狼疮 肺损害 急性狼疮性肺炎 间质性肺病 弥漫性肺泡出血 肺动脉高压 

分 类 号：R593.241[医药卫生—内科学]